INT177457

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Context Info
Confidence 0.16
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.47
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
astrocytes 2
fibroblast 2
Il1 (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 57 100.00 Very High Very High Very High
cytokine 47 100.00 Very High Very High Very High
Inflammation 36 100.00 Very High Very High Very High
Inflammatory mediators 3 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
metalloproteinase 1 100.00 Very High Very High Very High
rheumatoid arthritis 36 95.64 Very High Very High Very High
Osteoarthritis 11 95.36 Very High Very High Very High
Arthritis 40 92.96 High High
Multiple sclerosis 2 91.12 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 36 100.00 Very High Very High Very High
Cancer 4 99.32 Very High Very High Very High
Granuloma 92 99.08 Very High Very High Very High
Necrosis 4 99.08 Very High Very High Very High
Targeted Disruption 44 97.96 Very High Very High Very High
Rheumatoid Arthritis 36 95.64 Very High Very High Very High
Osteoarthritis 11 95.36 Very High Very High Very High
Infection 13 95.24 Very High Very High Very High
Injury 55 94.80 High High
Arthritis 46 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1 subsequently increases the production of inflammatory mediators, such as cyclooxygenase 2, prostanoids, nitric oxide, matrix metalloproteinases, collagenase [17], and pro-inflammatory cytokines, including Interleukin-6 (IL-6) [18,19], tumor necrosis factor alpha (TNF-?)
IL-1 Positive_regulation (increases) of Gene_expression (production) of Interleukin-6 associated with necrosis, inflammatory mediators, inflammation, cancer, metalloproteinase, cox2 and cytokine
1) Confidence 0.16 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 1.70 Pain Relevance 0.58
IL-6 production in human peripheral blood mononuclear cells, bronchial cells, and astrocytes is increased directly by SP through the action of nuclear factor IL-6 (NF-IL-6) and p38 MAPK, as well as indirectly in response to IL-1?
IL-1 Positive_regulation (increased) of Gene_expression (production) of IL-6 in astrocytes associated with substance p
2) Confidence 0.06 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 1.61 Pain Relevance 0.30
The IL-1-induced expression of IL-6, IL-8, and granulocyte/macrophage-colony-stimulating factor (GM-CSF) was studied by ELISA in supernatant of RA and osteoarthritis fibroblast-like synoviocytes incubated with IFN-?.
IL-1 Positive_regulation (induced) of Gene_expression (expression) of IL-6 in fibroblast associated with rheumatoid arthritis and osteoarthritis
3) Confidence 0.06 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC416442 Disease Relevance 1.16 Pain Relevance 0.46

General Comments

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