INT177459

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Context Info
Confidence 0.25
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 7.90
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
arms 1
knee 1
RCT (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 147 100.00 Very High Very High Very High
Pain 119 99.68 Very High Very High Very High
Inflammation 60 97.32 Very High Very High Very High
analgesia 1 95.92 Very High Very High Very High
agonist 60 92.08 High High
Angina 12 90.72 High High
Bile 16 88.76 High High
complementary and alternative medicine 123 88.08 High High
imagery 19 77.84 Quite High
Analgesic 5 75.08 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 149 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 1152 99.84 Very High Very High Very High
Pain 99 99.68 Very High Very High Very High
Emergencies 42 98.72 Very High Very High Very High
Colon Cancer 98 97.84 Very High Very High Very High
INFLAMMATION 61 97.32 Very High Very High Very High
Staphylococcus Infection 46 97.20 Very High Very High Very High
Musculoskeletal Disease 1 94.88 High High
Cv General 3 Under Development 12 90.72 High High
Myocardial Infarction 77 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expected value of participation is positive – it is of greater value to the participant than declining the RCT and accepting usual care, and the study is ethically sound – but it does not meet the weaker principle of 'equipoise' or 'uncertainty'.
Negative_regulation (declining) of RCT
1) Confidence 0.25 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416446 Disease Relevance 0.52 Pain Relevance 0.48
The standard becomes the expected value of outcomes after declining the RCT (usual care) as compared with the average expected value of outcomes after accepting the trial.
Negative_regulation (declining) of RCT
2) Confidence 0.25 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416446 Disease Relevance 0.35 Pain Relevance 0.31
The principle of 'equal uncertainty between the arms of the RCT' must be replaced with the principle of a reasonable 'expected value' for the participant after pooling the RCT arms.
Negative_regulation (pooling) of RCT in arms
3) Confidence 0.25 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416446 Disease Relevance 0.32 Pain Relevance 0.28
Hrobartsson and Gotzsche [23] reviewed 29 RCT's of a wide variety of organic and musculoskeletal pain complaints and conditions which used placebo analgesia control groups.
Negative_regulation (reviewed) of RCT associated with pain and analgesia
4) Confidence 0.22 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1553445 Disease Relevance 0.40 Pain Relevance 0.50
Cheung et al. recently published a RCT comparing endolaparoscopic approach (24 pts) vs. conventional open surgery (24 pts).
Negative_regulation (published) of RCT
5) Confidence 0.22 Published 2010 Journal World J Emerg Surg Section Body Doc Link PMC3022691 Disease Relevance 0.49 Pain Relevance 0
Lim et al in 2005 published the only RCT comparing ICI (24 patients) with MD (25 patients) in OLCC.
Negative_regulation (published) of RCT associated with colon cancer
6) Confidence 0.22 Published 2010 Journal World J Emerg Surg Section Body Doc Link PMC3022691 Disease Relevance 0.75 Pain Relevance 0.03
Before discussing the RCT in detail, it is important to identify limitations to the effectiveness of the RCT in measuring the efficacy of interventions in medical science generally.
Negative_regulation (effectiveness) of RCT
7) Confidence 0.16 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952302 Disease Relevance 0 Pain Relevance 0.08
However, complete abolition of CETP activity results in large, cholesterol-laden, dysfunctional HDL-C with reduced cholesterol efflux RCT capacity (Yamashita et al 1988; Sakai et al 1991; Ikewaki et al 1995).
Negative_regulation (reduced) of RCT associated with disorder of lipid metabolism
8) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.90 Pain Relevance 0
The adverse outcomes of the ILLUMINATE study may have been related to off-target effects of torcetrapib, such as an increase in systolic blood pressure (limited to 1–2 mmHg) or low levels of CETP inhibition and reduced RCT (Honey 2007).
Negative_regulation (inhibition) of RCT in blood
9) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.65 Pain Relevance 0.09
The adverse outcomes of the ILLUMINATE study may have been related to off-target effects of torcetrapib, such as an increase in systolic blood pressure (limited to 1–2 mmHg) or low levels of CETP inhibition and reduced RCT (Honey 2007).
Negative_regulation (reduced) of RCT in blood
10) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.65 Pain Relevance 0.09
The clinical significance of FSE as a marker of RCT remains uncertain.
Negative_regulation (marker) of RCT
11) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.02 Pain Relevance 0.09
The case group consisted of 205 women who contacted a breastfeeding clinic in southern Sweden during 2002 – 2004 because of inflammatory symptoms of the breast during lactation and had agreed to join a randomised controlled trial of care interventions [4]; registration number of the RCT is: NCT00405158.
Negative_regulation (number) of RCT associated with inflammation
12) Confidence 0.04 Published 2008 Journal Int Breastfeed J Section Body Doc Link PMC2322959 Disease Relevance 0.71 Pain Relevance 0.05
While both the expertise-based and conventional RCT designs are accepted methodologies and will be implemented in this study to minimize potential biases, it is appropriate to evaluate the impact of these designs on the results of the study.
Negative_regulation (implemented) of RCT
13) Confidence 0.02 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1421402 Disease Relevance 0.21 Pain Relevance 0.04
In a double-blind RCT on knee OA, after crossover at 6 months, but not at 3 months before crossover, 250 mg of an extract of Z. officinale four times a day reduced VAS of pain and handicap more efficiently than placebo [112].
Negative_regulation (reduced) of RCT in knee associated with pain and osteoarthritis
14) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779427 Disease Relevance 0.93 Pain Relevance 0.67

General Comments

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