INT177467

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Context Info
Confidence 0.05
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 11.84
Pain Relevance 5.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTRF1) cytoplasm (MTRF1)
Anatomy Link Frequency
B-cell 1
MTRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 700 99.84 Very High Very High Very High
Adalimumab 440 99.68 Very High Very High Very High
Infliximab 276 99.66 Very High Very High Very High
methotrexate 211 97.80 Very High Very High Very High
Etanercept 76 97.76 Very High Very High Very High
cytokine 9 94.72 High High
Inflammation 36 91.32 High High
Arthritis 14 88.56 High High
Migraine 4 51.52 Quite High
carpal tunnel syndrome 1 32.04 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 701 99.84 Very High Very High Very High
Disease 265 98.48 Very High Very High Very High
Malignant Neoplastic Disease 10 95.88 Very High Very High Very High
Cryoglobulinemia 146 95.80 Very High Very High Very High
Lymphatic System Cancer 17 94.80 High High
Syndrome 82 93.96 High High
Systemic Lupus Erythematosus 125 93.56 High High
INFLAMMATION 43 91.32 High High
Arthritis 21 88.56 High High
Hepatocellular Cancer 4 87.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No reliable markers predictive for the clinical response have been identified, although a recent report suggests that a decrease in rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody titers might be a useful adjunct in assessing the efficacy of treatment [6].
Negative_regulation (decrease) of RF
1) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.55 Pain Relevance 0.23
A decrease in RF and anti-CCP antibody titers has been recently correlated with clinical improvement after infliximab therapy in patients with RA [6-8].
Negative_regulation (decrease) of RF associated with infliximab and rheumatoid arthritis
2) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.82 Pain Relevance 0.53
In contrast, results of studies on the association between the response to conventional RA treatment and the decrease in RF and/or anti-CCP autoantibodies have been inconsistent.
Negative_regulation (decrease) of RF associated with rheumatoid arthritis
3) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.55 Pain Relevance 0.38
A decrease in serum RF levels has been reported in association with successful treatment with methotrexate and gold salts [40].
Negative_regulation (decrease) of RF associated with methotrexate
4) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.60 Pain Relevance 0.43
When we grouped the patients on the basis of their clinical response (ACR improvement criteria) to adalimumab, a significant decrease in RF serum titers was observed in those who were clinically improved according to ACR 20 and ACR 50 at weeks 24 and 48, whereas a decrease was also found for ACR 70 at week 48 (Table 3).
Negative_regulation (decrease) of RF associated with adalimumab
5) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.14 Pain Relevance 0.16
The Spearman's correlation coefficient of the improvement in the DAS 28 values with the decrease in RF titer at week 48 was 0.316 (p = 0.018), and that for the anti-CCP autoantibodies titer was 0.33 (p = 0.013).
Negative_regulation (decrease) of RF
6) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.25 Pain Relevance 0.40
Such an effect is associated with a decrease in serum levels of RF and anti-CCP antibody levels, which was detected after 24 weeks and remained stable until 48 weeks of treatment.
Negative_regulation (decrease) of RF
7) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.36 Pain Relevance 0.16
Recently, two papers showed a decrease in RF and anti-CCP antibody titers in patients with RA treated with infliximab [6,8].
Negative_regulation (decrease) of RF associated with infliximab and rheumatoid arthritis
8) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.59 Pain Relevance 0.30
The decline of RF was correlated with the reduction of disease activity (DAS-28 and CRP); on the contrary, the anti-CCP titer was not statistical significantly correlated to disease activity (DAS-28 and CRP).
Negative_regulation (decline) of RF associated with disease
9) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727907 Disease Relevance 0.51 Pain Relevance 0.09
Treatment with adalimumab induced a significant decrease in RF and anti-CCP serum levels, and the decrease in antibody titers correlated with the clinical response to the therapy.
Negative_regulation (decrease) of RF associated with adalimumab
10) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526573 Disease Relevance 0.42 Pain Relevance 0.39
However, whereas RF titer reduction was also reported by other groups after infliximab and etanercept therapy [7,8,10,11,37-39], contrasting results were found for anti-CCP antibody levels [7,8,10,11,37-39].
Negative_regulation (reduction) of RF associated with infliximab and etanercept
11) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.65 Pain Relevance 0.42
A decrease in IgM-RF titers was initially described by Charles and colleagues in a small series of patients receiving infliximab [7], but then inconsistent findings were reported [8-11].
Negative_regulation (decrease) of RF associated with infliximab
12) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.54 Pain Relevance 0.24
Statistical analysis has shown no differences in clinical response, between RF positive/negative patients, and anti-CCP-positive/negative patients, while decline of RF was better correlated with reduction of DAS-28 than with anti-CCP.


Negative_regulation (decline) of RF
13) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2727907 Disease Relevance 0.45 Pain Relevance 0.10
RF decreased statistically significant and was correlated with the reduction of DAS-28 and CRP, while anti-CCP did not correlate with the reduction of DAS-28 and CRP as a measure of disease activity.
Negative_regulation (decreased) of RF associated with disease
14) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727907 Disease Relevance 0.53 Pain Relevance 0.25
Decline of RF was associated with clinical response and reduction of DAS-28 and CRP.



Negative_regulation (Decline) of RF
15) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2727907 Disease Relevance 0.23 Pain Relevance 0.05
The positive numbers of anti-CCP, AFA, and RF were 3 (1.3%), 73 (25.5%), and 42 (14.7%) at the optimal cut off values, respectively.
Negative_regulation (numbers) of RF
16) Confidence 0.02 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782206 Disease Relevance 0.36 Pain Relevance 0.10
The decrease in RF titre roughly paralleled DAS 28 values, suggesting that this measure could be regarded as an additional marker of disease activity, although we did not find significant correlations between changes in RF and ACR response.
Negative_regulation (decrease) of RF associated with disease
17) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416448 Disease Relevance 0.41 Pain Relevance 0.27
The reduction in RF titre was more pronounced and persistent than that of anti-CCP antibodies, suggesting that the production of these antibodies may follow different regulatory pathways.


Negative_regulation (reduction) of RF
18) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416448 Disease Relevance 0.60 Pain Relevance 0.22
Our data also suggest that generation of RF and anti-CCP antibodies may be controlled in a different manner in RA, because inhibition of RF appears to be more dependent on TNF-?
Negative_regulation (inhibition) of RF associated with rheumatoid arthritis
19) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416448 Disease Relevance 0.39 Pain Relevance 0.31
No differences in RF and anti-CCP antibody positivity were observed even though a significant reduction in RF and anti-CCP antibody titres was found during the course of treatment.
Negative_regulation (reduction) of RF
20) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416448 Disease Relevance 0.61 Pain Relevance 0.24

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