INT177468

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTRF1) cytoplasm (MTRF1)
Anatomy Link Frequency
synovium 2
MTRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Infliximab 62 99.92 Very High Very High Very High
Inflammation 4 98.64 Very High Very High Very High
rheumatoid arthritis 50 98.08 Very High Very High Very High
methotrexate 14 96.28 Very High Very High Very High
Etanercept 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 98.64 Very High Very High Very High
Rheumatoid Arthritis 50 98.08 Very High Very High Very High
Urological Neuroanatomy 8 76.60 Quite High
Disease 18 59.96 Quite High
Thrombosis 2 46.84 Quite Low
Anti-phospholipid Antibody Syndrome 4 40.96 Quite Low
Systemic Lupus Erythematosus 26 38.32 Quite Low
Syndrome 4 37.84 Quite Low
Bacterial Infection 2 21.64 Low Low
Apoptosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased production of RF has been reported in association with successful treatment with conventional DMARDs such as methotrexate and gold salts [21].
Negative_regulation (Decreased) of Gene_expression (production) of RF associated with methotrexate
1) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416448 Disease Relevance 0.44 Pain Relevance 0.30
Because RF-producing cells are present in inflamed rheumatoid synovium and the local environment may favour synovial RF production [40], we can speculate that the reduction in inflammatory lymphoplasmacytic infiltrate in rheumatoid synovium will lead to a reduced production of RF.
Negative_regulation (reduced) of Gene_expression (production) of RF in synovium associated with inflammation
2) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416448 Disease Relevance 0.39 Pain Relevance 0.29

General Comments

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