INT177468

Context Info Confidence 0.03 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.83 Pain Relevance 0.58

mitochondrion (MTRF1) cytoplasm (MTRF1)

Anatomy Link Frequency synovium 2 MTRF1 (Homo sapiens)

Pain Link Frequency Relevance Heat Infliximab 62 99.92 Inflammation 4 98.64 rheumatoid arthritis 50 98.08 methotrexate 14 96.28 Etanercept 4 5.00 cytokine 2 5.00 cINOD 2 5.00 spinal inflammation 2 5.00 Crohn's disease 2 5.00 Arthritis 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 6 98.64 Rheumatoid Arthritis 50 98.08 Urological Neuroanatomy 8 76.60 Disease 18 59.96 Thrombosis 2 46.84 Anti-phospholipid Antibody Syndrome 4 40.96 Systemic Lupus Erythematosus 26 38.32 Syndrome 4 37.84 Bacterial Infection 2 21.64 Apoptosis 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Decreased production of RF has been reported in association with successful treatment with conventional DMARDs such as methotrexate and gold salts [21].

Negative_regulation (Decreased) of Gene_expression (production) of RF associated with methotrexate

1) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416448 Disease Relevance 0.44 Pain Relevance 0.30

Because RF-producing cells are present in inflamed rheumatoid synovium and the local environment may favour synovial RF production [40], we can speculate that the reduction in inflammatory lymphoplasmacytic infiltrate in rheumatoid synovium will lead to a reduced production of RF.

Negative_regulation (reduced) of Gene_expression (production) of RF in synovium associated with inflammation

2) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416448 Disease Relevance 0.39 Pain Relevance 0.29

General Comments

This test has worked.