INT177471

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Context Info
Confidence 0.06
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.46
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTRF1) cytoplasm (MTRF1)
MTRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Infliximab 73 99.24 Very High Very High Very High
rheumatoid arthritis 161 99.00 Very High Very High Very High
Adalimumab 40 93.80 High High
methotrexate 41 86.12 High High
fibrosis 2 85.96 High High
Pain 1 76.84 Quite High
antagonist 2 75.92 Quite High
Inflammation 21 72.20 Quite High
cytokine 9 70.56 Quite High
Arthritis 3 23.00 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 161 99.00 Very High Very High Very High
Disease 58 95.40 Very High Very High Very High
Syndrome 8 89.84 High High
Spinal Cord Diseases 1 87.32 High High
Urological Neuroanatomy 8 87.24 High High
Nerve Compression Syndromes 1 86.68 High High
Pulmonary Fibrosis 2 85.96 High High
Increased Venous Pressure Under Development 1 85.16 High High
Cancer 12 81.04 Quite High
Necrosis 10 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A strong correlation between anti-CCP and RF at baseline was observed (?
Localization (correlation) of RF
1) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.18 Pain Relevance 0.17
Patient response to treatment was independent to the presence of RF and anti-CCP antibodies.
Localization (presence) of RF
2) Confidence 0.05 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727907 Disease Relevance 0.50 Pain Relevance 0.09
RF is found in 80% of patients with RA, but also may be found in normal individuals.
Localization (found) of RF associated with rheumatoid arthritis
3) Confidence 0.04 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 1.84 Pain Relevance 0.58
The decrease in RF titre roughly paralleled DAS 28 values, suggesting that this measure could be regarded as an additional marker of disease activity, although we did not find significant correlations between changes in RF and ACR response.
Localization (decrease) of RF associated with disease
4) Confidence 0.04 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416448 Disease Relevance 0.41 Pain Relevance 0.27
Although we did not identify any change in the number of positive patients, in the present study we found a significant decrease in the titres of both anti-CCP antibodies and RF after 30 weeks of infliximab therapy.
Localization (decrease) of RF associated with infliximab
5) Confidence 0.04 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416448 Disease Relevance 0.53 Pain Relevance 0.29

General Comments

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