INT177480

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Context Info
Confidence 0.06
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.46
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Crh, POMC) extracellular space (Crh, POMC) extracellular region (Crh, POMC)
small molecule metabolic process (POMC) cell-cell signaling (POMC) response to stress (Crh)
Anatomy Link Frequency
anterior pituitary 3
Crh (Rattus norvegicus)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 18 96.36 Very High Very High Very High
dexamethasone 3 90.52 High High
substance P 24 51.04 Quite High
Serotonin 35 50.40 Quite High
Fibrositis 92 50.00 Quite Low
Neurotransmitter 10 50.00 Quite Low
Pain 19 12.52 Low Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
Lasting pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 18 96.36 Very High Very High Very High
Stress 61 68.40 Quite High
Fibromyalgia 92 50.00 Quite Low
Congenital Anomalies 15 21.12 Low Low
Pain 22 12.52 Low Low
Nociception 5 5.00 Very Low Very Low Very Low
Fatigue 3 5.00 Very Low Very Low Very Low
Growth Hormone Deficiency 3 5.00 Very Low Very Low Very Low
Endometriosis (extended) 3 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In CRH deficiency states there is an exaggerated ACTH response due to upregulation of CRH receptors in the anterior pituitary, while in conditions of CRH excess, such as classical depression, the ACTH response is muted.
Positive_regulation (upregulation) of CRH in anterior pituitary Positive_regulation (due) of Regulation (response) of ACTH in anterior pituitary associated with depression
1) Confidence 0.06 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416451 Disease Relevance 0.46 Pain Relevance 0.14

General Comments

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