INT17749

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Context Info
Confidence 0.23
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 8.02
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cartilage 2
uterine 2
glomerulus 2
sympathetic nervous system 2
MRXS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 13 100.00 Very High Very High Very High
cytokine 60 99.82 Very High Very High Very High
Inflammation 114 99.62 Very High Very High Very High
IPN 5 98.76 Very High Very High Very High
cINOD 63 98.40 Very High Very High Very High
withdrawal 9 97.68 Very High Very High Very High
Neuropathic pain 9 97.40 Very High Very High Very High
antagonist 24 94.72 High High
Spinal cord 16 92.24 High High
Osteoarthritis 53 88.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 144 100.00 Very High Very High Very High
Stress 45 99.60 Very High Very High Very High
Inflammatory Pain 5 98.76 Very High Very High Very High
Malignant Neoplastic Disease 3 97.48 Very High Very High Very High
Neuropathic Pain 15 97.40 Very High Very High Very High
Apoptosis 133 95.48 Very High Very High Very High
Cancer 229 94.48 High High
Pancreatitis 2 92.56 High High
Nicotine Addiction 2 88.68 High High
Osteoarthritis 56 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The bulk of available evidence suggests that the glomerulus is the target structure for many vasoconstrictor agents, which stimulate renal synthesis of vasodilator PGs.
Positive_regulation (stimulate) of Gene_expression (synthesis) of PGs in glomerulus
1) Confidence 0.23 Published 1984 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 6442643 Disease Relevance 0.07 Pain Relevance 0.07
These data clearly indicate that the increased renal synthesis of vasodilating PGs has a relevant role in maintaining renal hemodynamics, sodium and water excretion in a clinical setting characterized by a reduction of effective plasma volume and a striking activation of the major vasoconstricting systems, namely the renin-angiotensin-aldosterone, the sympathetic nervous system, and vasopressin.
Positive_regulation (increased) of Gene_expression (synthesis) of PGs in sympathetic nervous system
2) Confidence 0.23 Published 1997 Journal Semin. Nephrol. Section Abstract Doc Link 9353864 Disease Relevance 0.32 Pain Relevance 0.18
The efficacy of Al.AAs is thought to be due to neutralizing properties and to stimulation of endogenous PGs synthesis.
Positive_regulation (stimulation) of Gene_expression (synthesis) of PGs
3) Confidence 0.19 Published 1991 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 1940188 Disease Relevance 0.44 Pain Relevance 0
Two isoforms, one constitutive (COX-1) and the other inducible (COX-2) exist, but in human labor it is the COX-2 enzyme that converts free arachidonic acid (produced from glycophospholipids in the cell membrane by increased phospholipase activity) into the PG precursors – PGH-2 and PGG-2.68,69 Triggers such as increased cortisol from maternal or fetal stress and/or inflammatory cytokines lead to increased production of PGs which override uterine quiescence, leading to functional withdrawal of progesterone.


Positive_regulation (increased) of Gene_expression (production) of PGs in uterine associated with stress, inflammation, withdrawal and cytokine
4) Confidence 0.08 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0.27 Pain Relevance 0.27
Cortisol leads to activation of p450 dependent placental 17 alpha hydroxylase and 17–20 lyase enzymes to cause conversion of C21 to C18 steroids.56 Maternal estradiol levels rise, and progesterone levels fall, and this change in estrogen: progesterone ratio leads to increased production of prostaglandins (PGs).
Positive_regulation (increased) of Gene_expression (production) of PGs
5) Confidence 0.05 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0.37 Pain Relevance 0.03
Tissue damage induces an inflammatory response including the production of prostaglandins (PGs) such as PGE2, which activate the EP1 receptor expressed by sensory fibres.
Positive_regulation (induces) of Gene_expression (production) of PGs associated with inflammatory response
6) Confidence 0.04 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.60 Pain Relevance 0.55
targeting the COX-2 inducible production of PGs.
Positive_regulation (inducible) of Gene_expression (production) of PGs
7) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 1.55 Pain Relevance 0.93
The former is a constitutive enzyme that is expressed in many cells as a house-keeping enzyme and stimulates homeostatic production of PGs.
Positive_regulation (stimulates) of Gene_expression (production) of PGs
8) Confidence 0.04 Published 2004 Journal Crit Care Section Body Doc Link PMC1065065 Disease Relevance 1.02 Pain Relevance 0.63
The enhanced production of the cartilage-specific phenotypic markers, PGs and type II collagen, by MPCs in the presence of PPS was demonstrated in MMC using a quantitative radiochemical assay and semiquantitatively by immunostaining with a type II collagen antibody.
Positive_regulation (enhanced) of Gene_expression (production) of PGs in cartilage
9) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.11 Pain Relevance 0
Evidence from other systems points to potential links between oxidative stress and COX induction, resulting in the production of PGs [12–16].
Positive_regulation (resulting) of Gene_expression (production) of PGs associated with stress
10) Confidence 0.02 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.42 Pain Relevance 0.03
Once formed by COX-1 or COX-2, the unstable PGH2 intermediate is metabolized by specific PG synthase enzymes to generate the classical bioactive PGs, including PGE2, PGD2, PGF2?
Positive_regulation (generate) of Gene_expression (generate) of PGs
11) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.42 Pain Relevance 0.22
It seems likely that increased production of both PGs is mediated by the increased Cox-2 and PLA2 activity associated with luteolysis.
Positive_regulation (increased) of Gene_expression (production) of PGs
12) Confidence 0.02 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293427 Disease Relevance 0 Pain Relevance 0.03
Cytokine-mediated up-regulation of COX-2 contributes to increased synthesis of PGs in inflamed tissues [119-122].
Positive_regulation (increased) of Gene_expression (synthesis) of PGs associated with cytokine
13) Confidence 0.01 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.21 Pain Relevance 0.10
Cytokine-mediated up-regulation of COX-2 contributes to increased synthesis of PGs in inflamed tissues [119-122].
Positive_regulation (contributes) of Gene_expression (synthesis) of PGs associated with cytokine
14) Confidence 0.01 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.22 Pain Relevance 0.10
Production of both PGs was significantly enhanced compared to non-transfected cells and the increase in PGE2 was significantly greater than that of PGF2?.
Positive_regulation (enhanced) of Gene_expression (Production) of PGs
15) Confidence 0.01 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1868772 Disease Relevance 0 Pain Relevance 0

General Comments

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