INT177492

Context Info Confidence 0.45 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.25 Pain Relevance 1.09

aging (Slc32a1)

Anatomy Link Frequency testis 1 brain 1 Slc32a1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 78 99.98 GABAergic 62 99.68 Neurotransmitter 10 96.40 gABA 101 93.44 Substantia nigra 73 92.84 Action potential 5 85.68 tetrodotoxin 14 84.36 Spinal cord 46 82.80 Calcium channel 1 67.72 imagery 6 49.64

Disease Link Frequency Relevance Heat Brain Hemorrhage 6 99.98 Cv Unclassified Under Development 72 91.80 Disease 16 87.68 Generalized Anxiety Disorder 33 87.24 Middle Cerebral Artery Infarction 3 56.56 Anaerobic Bacterial Infections 22 50.00 Death 2 47.60 Central Nervous System Disease 1 11.80 Injury 20 6.40 Parkinson's Disease 16 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Quantitative analysis revealed a 3-fold increase in the fluorescence intensity of HCR/T at excitatory terminals (vGLUT1) and a 10-fold increase at inhibitory terminals (vGAT) upon stimulation with high potassium (Figure 1B).

Positive_regulation (increase) of vGAT

1) Confidence 0.45 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.09 Pain Relevance 0.47

Recent studies reported that focal brain ischemia decreases VGAT in the injured brain regions during the 72 hours after reperfusion [40].

Positive_regulation (decreases) of VGAT in brain associated with brain hemorrhage and ischemia

2) Confidence 0.41 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.93 Pain Relevance 0.56

The GABAergic system is also present in postnatal mouse testis: GAD67, VGAT and several GABAA receptor subunits in postnatal mouse testis

Positive_regulation (present) of VGAT in testis associated with gabaergic

3) Confidence 0.17 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC416489 Disease Relevance 0.23 Pain Relevance 0.05

General Comments

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