INT17750

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Context Info
Confidence 0.56
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 6.65
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
platelet 1
fibroblasts 1
uterine 1
microglia 1
urine 1
MRXS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 118 99.84 Very High Very High Very High
glial activation 4 99.40 Very High Very High Very High
substance P 1 98.84 Very High Very High Very High
excitatory amino acid 1 98.32 Very High Very High Very High
Inflammatory response 13 97.60 Very High Very High Very High
adenocard 1 97.24 Very High Very High Very High
cytokine 66 92.72 High High
Pain 26 89.04 High High
IPN 5 87.64 High High
allodynia 5 86.48 High High
Disease Link Frequency Relevance Heat
Stress 51 100.00 Very High Very High Very High
INFLAMMATION 149 99.84 Very High Very High Very High
Sepsis 53 99.56 Very High Very High Very High
Disease 144 97.32 Very High Very High Very High
Injury 46 96.12 Very High Very High Very High
Fibrosis 5 95.52 Very High Very High Very High
Ulcers 1 92.48 High High
Fever 11 89.48 High High
Pain 21 89.04 High High
Anaplastic Astrocytoma 1 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The stimulatory effect of low doses of CuCl2 seen after instillation into the uterine cavity is largely exerted via initiation of synthesis and release of endometrial PGs.
Localization (release) of PGs in uterine
1) Confidence 0.56 Published 1986 Journal Prostaglandins Section Abstract Doc Link 3464042 Disease Relevance 0.06 Pain Relevance 0.06
Renal PGs are, at least in part, excreted into urine.
Localization (excreted) of PGs in urine
2) Confidence 0.35 Published 1997 Journal Semin. Nephrol. Section Abstract Doc Link 9353864 Disease Relevance 0.23 Pain Relevance 0.14
Al-induced mucosal protection could be caused by a stimulated release of endogenous PGs, induced by Al microcrystal penetration of cells.
Localization (release) of PGs
3) Confidence 0.28 Published 1991 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 1940188 Disease Relevance 0.71 Pain Relevance 0
These results suggest a possible link between the release of PGs from activated microglia and the astrocytic synthesis of IL-6, which itself may affect neuronal cells, as hypothesized for Alzheimer's disease.
Localization (release) of PGs in neuronal associated with disease
4) Confidence 0.21 Published 1998 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 9850935 Disease Relevance 0.71 Pain Relevance 0.14
As the experimental curves used in parameter fitting corresponded to the abnormal metabolism of PGs and LTs, we used the parameter sets derived there to describe the disease state (see details in ‘The AAnetwork model in human PMN, endothelial and platelet cells').
Localization (metabolism) of PGs in platelet associated with disease
5) Confidence 0.13 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.52 Pain Relevance 0.07
Glial activation can be induced by substances released from neurones such as PGs, nitric oxide, fractalkine, substance P, excitatory amino acids and adenosine 5'-triphosphate (ATP) [26], and in turn, result in the release of numerous inflammatory agents such as cytokines, growth factors, kinins, purines, amines, prostanoids and ions [27].
Localization (released) of PGs associated with adenocard, inflammation, cytokine, excitatory amino acid, substance p and glial activation
6) Confidence 0.07 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.97 Pain Relevance 1.25
Whereas COX-1-generated PGs is implicated in homeostasis and survival of the foetus, and mainly secreted in decidual lining of the uterus [12,13] without modulation during gestation or labour.
Localization (secreted) of PGs in uterus
7) Confidence 0.05 Published 2010 Journal Malar J Section Body Doc Link PMC2831904 Disease Relevance 1.04 Pain Relevance 0.17
Fox and colleagues [32] postulated that the attenuated pulmonary and systemic vascular contractility observed in sepsis was secondary to the release of vasodilator PGs.
Localization (release) of PGs associated with sepsis
8) Confidence 0.04 Published 2004 Journal Crit Care Section Body Doc Link PMC1065065 Disease Relevance 0.66 Pain Relevance 0.39
Therefore, it is possible that PGs synthesized in this zone in response to oxidative stress are released into the maternal circulation.
Localization (released) of PGs associated with stress
9) Confidence 0.04 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.37 Pain Relevance 0.07
Cell that synthesize PGs (as determined by Cox expression) also have substantial expression of the PG transporter [27] and this may be important for release of the synthesized PGs.
Localization (release) of PGs
10) Confidence 0.03 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293427 Disease Relevance 0 Pain Relevance 0
In general, secretion of PGs appears to be elevated in the early corpus luteum (CL) and during the period of luteolysis.
Localization (secretion) of PGs in corpus luteum
11) Confidence 0.03 Published 2003 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC293427 Disease Relevance 0 Pain Relevance 0
Similarly, it seems likely that expression of PG transporters may be required to allow secretion of PGs from luteal cells; although this idea has never been tested.
Localization (secretion) of PGs in luteal cells
12) Confidence 0.03 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293427 Disease Relevance 0 Pain Relevance 0
On the other hand, it has recently been brought forward that COX-1 could be the mayor player in neuroinflammation by being predominantly localised in microglia and thus secrete PGs in response to microglia activation.
Localization (secrete) of PGs in microglia
13) Confidence 0.03 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866462 Disease Relevance 0.45 Pain Relevance 0.46
PGs secreted by inflammatory cells are important in early initiation of inflammatory responses.
Localization (secreted) of PGs associated with inflammatory response and inflammation
14) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.38 Pain Relevance 0.23
We hypothesize that the proliferating fibroblasts secrete PGs which then accumulate in tissues.
Localization (secrete) of PGs in fibroblasts
15) Confidence 0.01 Published 2006 Journal BMC Vet Res Section Body Doc Link PMC1459153 Disease Relevance 0.49 Pain Relevance 0.13

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