INT177505

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Context Info
Confidence 0.38
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.19
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR7) intracellular (CCR7) signal transducer activity (CCR7)
Anatomy Link Frequency
PDL-1 1
naive T cell 1
T cell 1
CCR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 6 92.64 High High
psoriasis 2 88.80 High High
cytokine 17 84.96 Quite High
Inflammation 46 70.48 Quite High
chemokine 25 64.52 Quite High
Chronic pancreatitis 10 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
spinal inflammation 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chlamydia Infection 88 100.00 Very High Very High Very High
Disease 16 99.84 Very High Very High Very High
Adenocarcinoma 90 99.36 Very High Very High Very High
Inflammatory Bowel Disease 3 93.56 High High
Rheumatoid Arthritis 6 92.64 High High
Psoriasis 2 88.80 High High
Lichen 1 72.68 Quite High
Eczema 1 72.08 Quite High
Candida Infection 1 71.12 Quite High
Skin Diseases 4 71.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mix of PDAC plasmas did not have any clear effects on CCR7, PDL-1, and DCIR (Figure 10A).
Neg (not) Spec (clear) Regulation (effects) of CCR7 in PDL-1 associated with adenocarcinoma
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.55 Pain Relevance 0
These data identify CCL21 expression by BEC as an important determinant for naive T cell migration to tertiary lymphoid tissues, and suggest the CCL21/CCR7 pathway as a therapeutic target in diseases associated with naive T cell recruitment.
Regulation (target) of CCR7 in naive T cell associated with disease
2) Confidence 0.15 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 1.29 Pain Relevance 0.34
Using HLA-B27-restricted Chlamydia peptides with higher binding scores, previously defined as immunodominant in Ct-ReA [10], we have generated tetramers and identified Chlamydia-peptide-specific T cell responses in four of six patients with Ct-ReA.
Regulation (cell resp) of Chlamydia-peptide-specific in T cell associated with chlamydia infection
3) Confidence 0.00 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.36 Pain Relevance 0.08

General Comments

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