INT177507

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.45
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PLN) protein complex (PLN)
Anatomy Link Frequency
skin 1
PLN (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 18 97.76 Very High Very High Very High
cytokine 8 89.52 High High
Inflammation 12 74.24 Quite High
rheumatoid arthritis 3 20.16 Low Low
psoriasis 2 16.32 Low Low
cINOD 9 5.00 Very Low Very Low Very Low
aspirin 6 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Contact Dermatitis 23 86.32 High High
Allergic Dermatitis 21 85.68 High High
INFLAMMATION 16 74.24 Quite High
Stress 1 63.76 Quite High
Candida Infection 1 44.04 Quite Low
Disease 3 37.36 Quite Low
Inflammatory Bowel Disease 3 21.08 Low Low
Rheumatoid Arthritis 3 20.16 Low Low
Psoriasis 2 16.32 Low Low
Leukemia 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, the ChIP findings and the results of luciferase assays (Fig. 3A and 3B) show that transactivation of the KBTBD10 promoter correlates with DNA binding whereas transactivation of the PLN promoter does not.
Positive_regulation (transactivation) of PLN
1) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
Such indirect binding may be difficult to detect with our ChIP assays and cannot be entirely excluded as a mechanism for the transactivation of the PLN promoter.
Positive_regulation (transactivation) of PLN
2) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
Chromatin was immunoprecipitated with anti-Flag antibody and the indicated segments of the KBTBD10 and PLN promoters were amplified by PCR.
Positive_regulation (amplified) of PLN
3) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2725295 Disease Relevance 0 Pain Relevance 0
It is worth mentioning that Cumberbatch et al [29] have shown that skin application of 10 % SLS in mice resulted in a significant elevation of DC numbers in PLN, which could also be mediated by up-regulation of this chemokine by dermal lymphatics in those animals.
Positive_regulation (elevation) of PLN in skin associated with chemokine
4) Confidence 0.07 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.45 Pain Relevance 0.25

General Comments

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