INT177509

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.43
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL21) extracellular region (CCL21) cell-cell signaling (CCL21)
Anatomy Link Frequency
lymph nodes 1
skin 1
naive T cell 1
CCL21 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 76 100.00 Very High Very High Very High
cytokine 20 98.90 Very High Very High Very High
Inflammation 86 98.72 Very High Very High Very High
rheumatoid arthritis 9 92.88 High High
psoriasis 6 89.04 High High
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenoma 36 99.84 Very High Very High Very High
Disease 16 99.84 Very High Very High Very High
INFLAMMATION 90 98.72 Very High Very High Very High
Contact Dermatitis 69 95.08 Very High Very High Very High
Inflammatory Bowel Disease 9 93.80 High High
Malignant Neoplastic Disease 19 93.28 High High
Rheumatoid Arthritis 9 92.88 High High
Cleidocranial Dysplasia 18 92.44 High High
Psoriasis 6 89.04 High High
Papillomavirus Infection 18 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, our group and others have demonstrated that up-regulation of CCL21 could also take place in dermal LEC from patients with other diseases.
Regulation (regulation) of CCL21 associated with disease
1) Confidence 0.45 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 1.28 Pain Relevance 0.31
These data identify CCL21 expression by BEC as an important determinant for naive T cell migration to tertiary lymphoid tissues, and suggest the CCL21/CCR7 pathway as a therapeutic target in diseases associated with naive T cell recruitment.
Regulation (target) of CCL21 in naive T cell associated with disease
2) Confidence 0.27 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 1.29 Pain Relevance 0.34
Several inflammatory cytokine genes (CXCL1, CXCL2, CXCL3, CCL20, IL8, CCL23, CCL19, CCL21, CCL5) are dysregulated in adenomas.
Regulation (dysregulated) of CCL21 associated with adenoma, inflammation and cytokine
3) Confidence 0.23 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017541 Disease Relevance 1.89 Pain Relevance 0.47
We found a weak expression of CCL21 in dermal LEC from normal skin; however after contact with several irritant agents, CCL21 was up-regulated.


Regulation (regulated) of CCL21 in skin
4) Confidence 0.23 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.65 Pain Relevance 0.32
After injection of dsRNA, we observed a down-regulation of the homeostatic chemokine CCL21, which attracts CCR7+ cells, such as DCs and naïve T cells, to lymph nodes.
Regulation (regulation) of homeostatic chemokine CCL21 in lymph nodes associated with chemokine
5) Confidence 0.21 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.32 Pain Relevance 0.22
Secondary measures will include:

(a) Rating scales completed by the observing researcher during the 30 minute treatment periods at one-minute intervals of the participant's predominant levels of engagement and affect.

Regulation (affect) of Secondary
6) Confidence 0.05 Published 2010 Journal BMC Geriatr Section Body Doc Link PMC2826333 Disease Relevance 0 Pain Relevance 0

General Comments

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