INT177525

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.22
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Anatomy Link Frequency
smooth muscle 2
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 10 99.60 Very High Very High Very High
Inflammation 142 98.32 Very High Very High Very High
rheumatoid arthritis 52 91.92 High High
Arthritis 30 91.44 High High
cytokine 132 85.48 High High
Leflunomide 24 74.80 Quite High
methotrexate 27 72.32 Quite High
dexamethasone 14 67.84 Quite High
chemokine 3 48.80 Quite Low
Potency 2 34.40 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 152 99.60 Very High Very High Very High
Pulmonary Disease 112 99.44 Very High Very High Very High
Disease 13 97.44 Very High Very High Very High
Asthma 63 96.00 Very High Very High Very High
Pressure And Volume Under Development 4 93.20 High High
Necrosis 5 92.80 High High
Granuloma 90 92.52 High High
Cancer 5 92.44 High High
Experimental Arthritis 3 92.16 High High
Rheumatoid Arthritis 52 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study used a combination of separate PDE 3 and PDE 4 inhibitor and not a dual/mixed compound which posses both PDE 3 and PDE 4 inhibitory potential.
Negative_regulation (posses) of Negative_regulation (inhibitory) of PDE 4
1) Confidence 0.28 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 1.02 Pain Relevance 0.35
Because PDE 4 is also expressed in airway smooth muscle and, in vitro, PDE 4 inhibitors relax lung smooth muscle, selective PDE 4 inhibitors are being developed for treating COPD.
Negative_regulation (developed) of Negative_regulation (inhibitors) of PDE 4 in smooth muscle associated with pulmonary disease
2) Confidence 0.16 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Abstract Doc Link PMC2699952 Disease Relevance 0.78 Pain Relevance 0.22
PDE4 inhibitor that reduces the
Negative_regulation (reduces) of Negative_regulation (inhibitor) of PDE4
3) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233982 Disease Relevance 1.72 Pain Relevance 0.50
These results suggest that PDE4 inhibitors may be
Negative_regulation (be) of Negative_regulation (inhibitors) of PDE4
4) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233982 Disease Relevance 1.37 Pain Relevance 0.51
Evaluation of antirheumatic drugs and PDE4 inhibitors
Negative_regulation (Evaluation) of Negative_regulation (inhibitors) of PDE4
5) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233982 Disease Relevance 0.32 Pain Relevance 0

General Comments

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