INT177526

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 21
Disease Relevance 11.13
Pain Relevance 5.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
lung 4
eosinophils 4
lymph node 1
blood 1
leucocytes 1
Il5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 391 100.00 Very High Very High Very High
Inflammatory mediators 3 100.00 Very High Very High Very High
antagonist 205 99.68 Very High Very High Very High
agonist 21 99.60 Very High Very High Very High
dexamethasone 96 99.48 Very High Very High Very High
Inflammation 552 99.26 Very High Very High Very High
Potency 4 95.92 Very High Very High Very High
metalloproteinase 2 89.12 High High
chemokine 38 88.84 High High
Inflammatory response 14 48.64 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 544 100.00 Very High Very High Very High
Asthma 512 99.82 Very High Very High Very High
Rhinitis 67 99.00 Very High Very High Very High
Hypersensitivity 396 98.68 Very High Very High Very High
Adhesions 36 98.52 Very High Very High Very High
Pneumonia 32 98.12 Very High Very High Very High
Targeted Disruption 29 97.56 Very High Very High Very High
Sprains And Strains 94 97.16 Very High Very High Very High
Disease 142 95.16 Very High Very High Very High
Infection 142 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a very recent study, Schuster et al. showed that IL-5 was significantly decreased after high dose of vitamin A in mice, which were not fully deficient in that vitamin [39].
Negative_regulation (decreased) of IL-5
1) Confidence 0.36 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.28 Pain Relevance 0.06
IL-5 and IL-13 levels in the tissue may also be reduced by a direct effect on Th2 cell cytokine elaboration.
Negative_regulation (reduced) of IL-5 in Th2 cell associated with cytokine
2) Confidence 0.25 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.35 Pain Relevance 0.39
Allergic airway inflammation was suppressed, which was exemplified by the reduction of leucocytes, eosinophils, IL-5 and IL-13 in the bronchoalveolar lavage fluid.
Negative_regulation (reduction) of IL-5 in eosinophils associated with inflammation and hypersensitivity
3) Confidence 0.23 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC2898835 Disease Relevance 1.42 Pain Relevance 0.14
the combining of PDE inhibitors resulted in no additive effects in the reduction of IL-5, and reduced the effects of the PDE 4 inhibitor on its own.


Negative_regulation (reduction) of IL-5
4) Confidence 0.23 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.07 Pain Relevance 0.11
In our study dexamethasone is able to significantly reduce cell number (total and eosinophil) and inflammatory mediators (IL-5, IL-4 and TNF-?)
Negative_regulation (reduce) of IL-5 in eosinophil associated with inflammatory mediators and dexamethasone
5) Confidence 0.23 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.97 Pain Relevance 0.79
The high concentration of IL-5 (126.6 ± 11.4 pg/ml) of the positive control group was significantly reduced by beta-escin treatment (90.0 ± 10.8 pg/ml), which was comparable to the reduction achieved by dexamethasone treatment (73.2 ± 12.8 pg/ml).
Negative_regulation (reduced) of IL-5 associated with dexamethasone
6) Confidence 0.23 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.32 Pain Relevance 0.32
Based on this study we decided to perform the collection of BALF for the evaluation of IL-5 and IL-13 cytokines at 15 h after the last challenge.
Negative_regulation (evaluation) of IL-5 associated with cytokine
7) Confidence 0.23 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.38 Pain Relevance 0.31
of asthma through suppression of IL-13, IL-5, IgE, eosinophils CCR3 expression, and CD11b
Negative_regulation (suppression) of IL-5 in eosinophils associated with asthma
8) Confidence 0.22 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.78 Pain Relevance 0.07
The inefficacy of anti-IL-13 on lung inflammation and tissue IL-5 levels reported here is in contrast to other reports in similar models where IL-5 was reduced in BALF by an IL-13 vaccine approach [19] or in lung homogenates, with an anti-IL-13 antibody [14].
Negative_regulation (reduced) of IL-5 in lung associated with inflammation and pneumonia
9) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.38 Pain Relevance 0.20
In this previous study decreases in IL-4, IL-5 and IL-13 were also demonstrated in ovalbumin stimulated lymph node cultures from H4R antagonist treated or H4R deficient mice, despite any effect on proliferation.
Negative_regulation (decreases) of IL-5 in lymph node associated with antagonist
10) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.29 Pain Relevance 0.44
The effect on eosinophilic inflammation may in part be due to the fact that IL-5 in the airways, as measured in BALF and in lung homogenate, was reduced in H4R antagonist treated animals, whereas anti-IL-13 treatment had little effect.
Negative_regulation (reduced) of IL-5 in lung associated with rhinitis, inflammation and antagonist
11) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.65 Pain Relevance 0.29
In addition, levels of IL-5 and IL-13 in OVA-stimulated culture supernatants were significantly decreased by H4R antagonist and anti-IL-13 treatment.
Negative_regulation (decreased) of IL-5 associated with antagonist
12) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.18 Pain Relevance 0.32
Anti-inflammatory effect of sTNFR was accompanied with reduction of T helper 2 cytokine levels including interleukin (IL)-4, IL-5 and IL-13 in BALF and vascular cell adhesion molecule 1 expression in lung tissue.


Negative_regulation (reduction) of IL-5 in lung associated with inflammation, adhesions and cytokine
13) Confidence 0.14 Published 2009 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2730622 Disease Relevance 0.95 Pain Relevance 0.24
We have observed significant reduction of BALF IL-4, IL-5, and IL-13 levels in the sTNFR-treated group compared with the OVA group, which is consistent with the results of previous studies.
Negative_regulation (reduction) of IL-5
14) Confidence 0.14 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0.57 Pain Relevance 0.27
Furthermore, even if this did not reach statistical significance, the same experiments also revealed that IL-13 and IL-5 levels are reduced in absence of CERK (Fig. 1).
Negative_regulation (reduced) of IL-5
15) Confidence 0.13 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.33 Pain Relevance 0.15
A trend for reduction of IL-5 levels (-45%; p = 0.07 in Cerk-/- vs WT) was seen for all 3 knock-out strains.
Negative_regulation (reduction) of IL-5 associated with targeted disruption and sprains and strains
16) Confidence 0.13 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.46 Pain Relevance 0.28
agonists have been shown to reduce IL4, IL5, and IL13 production from Tcells of mice with induced lung inflammation [38,49].
Negative_regulation (reduce) of IL5 in lung associated with inflammation, agonist and pneumonia
17) Confidence 0.13 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.51 Pain Relevance 0.36
Unexpectedly, an early and strong, yet transient, induction of expression of the Th2 cytokines IL-4, IL-5 and IL-13 was measured in pulmonary T cells by day 2, before clinical manifestations became noticeable (Figure 3).
Negative_regulation (measured) of IL-5 in T cells associated with cytokine
18) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.44 Pain Relevance 0.21
Of these three cytokines, IL-5 is the most specific to the eosinophil lineage and is responsible for selective terminal differentiation of eosinophils.9 IL-5 also stimulates the release of eosinophils from the bone marrow into the peripheral circulation.10 The critical role of IL-5 in regulating eosinophils in humans has been demonstrated in several clinical trials with humanized anti-IL-5 antibodies (mepolizumab and reslizumab), currently a non-FDA approved drug, which dramatically lowers eosinophil levels in the blood in part by preventing eosinophil maturation in the bone marrow with arrest at the myelocyte and metamyelocyte stages.11,12

Emigration from the marrow and lifespan of eosinophils in the circulation and tissues

Negative_regulation (differentiation) of IL-5 in eosinophils associated with lifespan and cytokine
19) Confidence 0.08 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.08 Pain Relevance 0.12
Allergic airway inflammation was suppressed, which was exemplified by the reduction of leucocytes, eosinophils, IL-5 and IL-13 in the bronchoalveolar lavage fluid.
Negative_regulation (reduction) of IL-5 in leucocytes associated with inflammation and hypersensitivity
20) Confidence 0.08 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC2898835 Disease Relevance 1.42 Pain Relevance 0.14

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