INT177527

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.50
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 47 99.68 Very High Very High Very High
Inflammation 160 98.36 Very High Very High Very High
dexamethasone 36 65.28 Quite High
Inflammatory response 5 63.20 Quite High
cytokine 31 47.36 Quite Low
chemokine 3 46.24 Quite Low
Potency 6 31.84 Quite Low
Inflammatory mediators 3 19.44 Low Low
Restless leg syndrome 3 7.04 Low Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 20 99.68 Very High Very High Very High
INFLAMMATION 165 98.36 Very High Very High Very High
Pulmonary Fibrosis 28 97.52 Very High Very High Very High
Disease 19 94.48 High High
Adhesions 3 79.76 Quite High
Asthma 40 74.52 Quite High
Pulmonary Disease 6 59.12 Quite High
Cardiovascular Disease 3 55.36 Quite High
Reprotox - General 2 6 53.20 Quite High
Pneumonia 7 28.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study used a combination of separate PDE 3 and PDE 4 inhibitor and not a dual/mixed compound which posses both PDE 3 and PDE 4 inhibitory potential.
Negative_regulation (posses) of PDE 4 Neg (not) Binding (combination) of
1) Confidence 0.28 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 1.04 Pain Relevance 0.32
To date, however, very little is known regarding the potential interaction between selective inhibitors of PDE 3, PDE 4 and PDE 5.
Negative_regulation (inhibitors) of PDE 4 Binding (interaction) of
2) Confidence 0.28 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.46 Pain Relevance 0.15
Our study used a combination of separate PDE 3 and PDE 4 inhibitor and not a dual/mixed compound which posses both PDE 3 and PDE 4 inhibitory potential.
Negative_regulation (inhibitor) of PDE 4 Neg (not) Binding (combination) of
3) Confidence 0.28 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.97 Pain Relevance 0.29
At first, PDE4 inhibition suppresses tissue fibrosis by partial elimination of pro-fibrotic environment, for instance by suppression of inflammatory cells infiltration, downregulation of TNF-?
Negative_regulation (suppresses) of PDE4 Neg (inhibition) Binding (inhibition) of associated with fibrosis and inflammation
4) Confidence 0.20 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 1.04 Pain Relevance 0.47

General Comments

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