INT177531

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.46
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 47 99.24 Very High Very High Very High
Inflammation 120 98.36 Very High Very High Very High
Inflammatory response 5 62.32 Quite High
dexamethasone 24 61.04 Quite High
cytokine 23 43.12 Quite Low
chemokine 2 42.00 Quite Low
Potency 4 27.60 Quite Low
Inflammatory mediators 2 15.20 Low Low
Restless leg syndrome 2 7.04 Low Low
agonist 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 20 99.24 Very High Very High Very High
INFLAMMATION 124 98.36 Very High Very High Very High
Pulmonary Fibrosis 28 97.52 Very High Very High Very High
Disease 14 94.48 High High
Adhesions 2 75.52 Quite High
Asthma 27 74.52 Quite High
Pulmonary Disease 5 59.12 Quite High
Cardiovascular Disease 2 55.36 Quite High
Reprotox - General 2 4 53.20 Quite High
Pneumonia 7 28.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas ablation of PDE4A or PDE4B had no effect, inactivation of the PDE4D gene prevented co-IP of PDE activity with the ?
PDE4A Binding (ablation) of
1) Confidence 0.29 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
Our study used a combination of separate PDE 3 and PDE 4 inhibitor and not a dual/mixed compound which posses both PDE 3 and PDE 4 inhibitory potential.
PDE 4 Neg (not) Binding (combination) of
2) Confidence 0.24 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.96 Pain Relevance 0.29
To date, however, very little is known regarding the potential interaction between selective inhibitors of PDE 3, PDE 4 and PDE 5.
PDE 4 Binding (interaction) of
3) Confidence 0.24 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.46 Pain Relevance 0.15
At first, PDE4 inhibition suppresses tissue fibrosis by partial elimination of pro-fibrotic environment, for instance by suppression of inflammatory cells infiltration, downregulation of TNF-?
PDE4 Neg (inhibition) Binding (inhibition) of associated with fibrosis and inflammation
4) Confidence 0.17 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 1.04 Pain Relevance 0.47

General Comments

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