INT177532

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.96
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
hippocampus 1
Pde5a (Mus musculus)
Pain Link Frequency Relevance Heat
depression 22 98.98 Very High Very High Very High
Inflammation 42 98.72 Very High Very High Very High
Hippocampus 16 98.32 Very High Very High Very High
GABAergic 30 92.92 High High
Central nervous system 30 86.08 High High
Neurotransmitter 22 84.08 Quite High
long-term potentiation 26 82.52 Quite High
Action potential 18 80.16 Quite High
Serotonin 22 73.12 Quite High
Glutamate 14 69.28 Quite High
Disease Link Frequency Relevance Heat
Depression 22 98.98 Very High Very High Very High
INFLAMMATION 43 98.72 Very High Very High Very High
Disease 5 98.60 Very High Very High Very High
Asthma 13 97.32 Very High Very High Very High
Reprotox - General 2 2 66.00 Quite High
Increased Venous Pressure Under Development 9 62.80 Quite High
Obsessive-compulsive Disorder 2 52.64 Quite High
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, despite the presence of the cGMP hydrolysing PDE 5 in airways, the potential anti-inflammatory actions of selective inhibitors has not been fully investigated.
Localization (presence) of cGMP hydrolysing PDE 5 associated with inflammation
1) Confidence 0.56 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.75 Pain Relevance 0.24
Finally, NO may also contribute to LTD by suppressing presynaptic excitatory transmitter release cGMP-dependently, as has been observed in the hippocampus (Zhang et al., 2006b) and the neuromuscular junction (Wang et al., 1995; Etherington & Everett, 2004).
Localization (release) of cGMP in hippocampus associated with depression and hippocampus
2) Confidence 0.25 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.20 Pain Relevance 0.48
Further downstream, untangling the molecular mechanisms of short-term and long-term alterations occurring as a result of cGMP elevation, particularly when PKG activation is involved, will be challenging.
Localization (elevation) of cGMP
3) Confidence 0.23 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.10

General Comments

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