INT177548

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Context Info
Confidence 0.01
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.87
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Tpr) molecular_function (Tpr)
Anatomy Link Frequency
myeloid cell 1
ovary 1
kidney 1
Tpr (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 11 99.98 Very High Very High Very High
dopamine receptor 1 81.92 Quite High
Inflammation 38 80.28 Quite High
adenocard 1 75.12 Quite High
rheumatoid arthritis 14 51.92 Quite High
Opioid 3 50.00 Quite Low
Central nervous system 3 49.16 Quite Low
Neurobehavioral 6 18.16 Low Low
cytokine 21 9.36 Low Low
metalloproteinase 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 58 99.84 Very High Very High Very High
Sprains And Strains 13 99.24 Very High Very High Very High
Repression 22 98.96 Very High Very High Very High
Lung Cancer 39 97.32 Very High Very High Very High
Obesity 151 94.84 High High
Insulin Resistance 34 93.88 High High
Autoimmune Disease 15 92.80 High High
Neuroblastoma 4 92.12 High High
Cytomegalovirus Infection 29 90.72 High High
Adhesions 3 82.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Role of the CAG promoter in kidney-targeted gene expression
Regulation (Role) of promoter in kidney
1) Confidence 0.01 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC419703 Disease Relevance 0.15 Pain Relevance 0
As previously shown, crossing IRflox/flox-mice with mice expressing the Cre-recombinase under control of the lysozymeM promoter resulted in efficient, myeloid cell-restricted ablation of the insulin receptor [19] (Figure 1A and 1B).
Regulation (control) of lysozymeM promoter in myeloid cell
2) Confidence 0.01 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.30 Pain Relevance 0.07
Heterozygous 2-loxP mice were mated to a transgenic strain expressing Cre recombinase under the control of the ovary-specific Zp3 promoter on a C57BL/6J background.
Regulation (control) of Zp3 promoter in ovary associated with targeted disruption and sprains and strains
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.27 Pain Relevance 0
Because of the observed sensitivity to modest changes in TetR levels, we next focused on further modifying the H1 promoter to ensure complete shRNA repression under limiting TetR levels.
Regulation (modifying) of promoter associated with repression
4) Confidence 0.01 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.44 Pain Relevance 0
opioid receptor promoter differentially depending on the cellular context.
Regulation (depending) of promoter associated with opioid receptor
5) Confidence 0.01 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0.16 Pain Relevance 0.12
under the control of the surfactant protein C promoter, which
Regulation (control) of promoter
6) Confidence 0.00 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.58 Pain Relevance 0
promoter under the control of surrounding cis-acting elements.
Regulation (under) of promoter
7) Confidence 0.00 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1140086 Disease Relevance 0.09 Pain Relevance 0
The GnRHR gene identified through microarray analysis has been validated as Foxl2 responsive through promoter cloning and reporter gene analysis.
Regulation (responsive) of promoter
8) Confidence 0.00 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.46 Pain Relevance 0.04
Constitutive expression of CD70 under the control of the CD19 promoter in transgenic mice leads to a persistent stimulation of CD27.
Regulation (control) of CD19 promoter associated with targeted disruption
9) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.43 Pain Relevance 0.03

General Comments

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