INT177554

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.08
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Calr) Golgi apparatus (Calr) endoplasmic reticulum (Calr)
cytoplasm (Calr) cytosol (Calr) protein folding (Calr)
Anatomy Link Frequency
myotube 2
Calr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 35 98.68 Very High Very High Very High
cytokine 2 51.60 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myositis 42 99.92 Very High Very High Very High
INFLAMMATION 30 98.68 Very High Very High Very High
Stress 29 95.40 Very High Very High Very High
Injury 6 94.16 High High
Sprains And Strains 4 77.64 Quite High
Congenital Anomalies 8 67.36 Quite High
American Trypanosomiasis 4 50.00 Quite Low
Diphtheria 3 50.00 Quite Low
Targeted Disruption 11 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of Grp94 and calreticulin characterized patients with a high percentage of regenerating myofibers; experimental studies showed that this ER stress-response occurred simultaneously with myotube maturation, therefore lacking specificity for myositis.
Positive_regulation (Increased) of Gene_expression (expression) of calreticulin in myotube associated with stress and myositis
1) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.91 Pain Relevance 0.14
The presence of cytosolic CRT in mammalian cells depends on CRT-C [31].
Positive_regulation (depends) of Gene_expression (presence) of CRT
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
Serum levels of CRT, an endogenous marker of renal function, were transiently elevated in the pCAG/DT-A/FuGENEĀ™6 complex-administered mice, with a peak at day 4, while the other biochemical markers including BUN, Na+, Cl-, and K+ were unaltered through day 4, and at weeks 3 and 5 (Figure 8).
Positive_regulation (elevated) of Gene_expression (levels) of CRT
3) Confidence 0.15 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC419703 Disease Relevance 0.16 Pain Relevance 0

General Comments

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