INT177555

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Context Info
Confidence 0.28
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.82
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Calr) Golgi apparatus (Calr) endoplasmic reticulum (Calr)
cytoplasm (Calr) cytosol (Calr) protein folding (Calr)
Anatomy Link Frequency
muscle fibers 2
Calr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 35 99.74 Very High Very High Very High
Calcium channel 7 72.24 Quite High
Central nervous system 7 5.00 Very Low Very Low Very Low
TRP channel 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myositis 42 99.96 Very High Very High Very High
Stress 29 98.28 Very High Very High Very High
Injury 6 94.16 High High
Congenital Anomalies 8 67.36 Quite High
INFLAMMATION 30 67.28 Quite High
Lysosomal Storage Diseases 24 50.64 Quite High
Diphtheria 3 50.00 Quite Low
Death 3 47.16 Quite Low
Lysosome Storage Disease 6 21.04 Low Low
Disease 18 19.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was therefore to investigate the stress-response ongoing in muscle fibers of patients affected with inflammatory myopathies, focusing on Grp94, calreticulin and Grp75 expression and distribution.
Regulation (focusing) of Gene_expression (expression) of calreticulin in muscle fibers associated with stress and inflammation
1) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.61 Pain Relevance 0.12
Serum levels of CRT, an endogenous marker of renal function, were transiently elevated in the pCAG/DT-A/FuGENEĀ™6 complex-administered mice, with a peak at day 4, while the other biochemical markers including BUN, Na+, Cl-, and K+ were unaltered through day 4, and at weeks 3 and 5 (Figure 8).
Regulation (unaltered) of Gene_expression (levels) of CRT
2) Confidence 0.14 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC419703 Disease Relevance 0.16 Pain Relevance 0
That the expression levels of GRP94, Hsp70, calnexin, and calreticulin were not changed significantly was also confirmed at the protein level.
Neg (not) Regulation (changed) of Gene_expression (expression) of calreticulin
3) Confidence 0.09 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0.05 Pain Relevance 0.04

General Comments

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