INT177568

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.82
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gpx1) mitochondrion (Gpx1) oxidoreductase activity (Gpx1)
nucleus (Gpx1) lipid metabolic process (Gpx1) cytoplasm (Gpx1)
Anatomy Link Frequency
blood 2
brain 2
Gpx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 26 94.16 High High
Opioid 1 77.80 Quite High
medulla 2 75.04 Quite High
tolerance 1 33.36 Quite Low
withdrawal 10 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 12 100.00 Very High Very High Very High
INFLAMMATION 27 94.16 High High
Cancer 33 92.64 High High
Atherosclerosis 9 90.16 High High
Necrosis 12 89.40 High High
Injury 5 88.88 High High
Diabetes Mellitus 13 88.16 High High
Increased Venous Pressure Under Development 3 84.36 Quite High
Nephrotoxicity 30 74.72 Quite High
Stress 52 71.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GPx2 (gastrointestinal GPx) and GPx5 (sperm nuclei GPx) have tissue specific localization, while the expression of GPx3 (extracellular GPx) was found to be extremely low in mouse brain 41.
Localization (localization) of GPx in brain
1) Confidence 0.49 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.19 Pain Relevance 0
GPx2 (gastrointestinal GPx) and GPx5 (sperm nuclei GPx) have tissue specific localization, while the expression of GPx3 (extracellular GPx) was found to be extremely low in mouse brain 41.
Localization (localization) of GPx in brain
2) Confidence 0.49 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.18 Pain Relevance 0
Antioxidant action is manifested by a decrease of malondialdehyde (MDA) formation via lipid peroxidation and an increase of hepatic antioxidative enzymes and antioxidants such as glutathione peroxidase (GPX), glutathione reductase (GR), catalase (CAT), superoxide dismutase (SOD) and glutathione S transferase (GST).
Localization (transferase) of GPX
3) Confidence 0.12 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.70 Pain Relevance 0.12
In our rats SAMC was able to ameliorate the decrease in creatinine clearance and blood GPx as well as the enhancement in BUN and in the urinary excretion of both total protein and NAG.
Localization (decrease) of GPx in blood associated with disorders of creatine metabolism
4) Confidence 0.07 Published 2004 Journal BMC Clin Pharmacol Section Body Doc Link PMC419708 Disease Relevance 0.59 Pain Relevance 0
As markers of tubular damage, we measured urinary excretion of NAG and total protein and blood GPx activity.
Localization (excretion) of GPx in blood
5) Confidence 0.07 Published 2004 Journal BMC Clin Pharmacol Section Body Doc Link PMC419708 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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