INT177584

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 80
Total Number 80
Disease Relevance 46.48
Pain Relevance 5.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MR1) endoplasmic reticulum (MR1) plasma membrane (MR1)
Anatomy Link Frequency
bone marrow 6
kidney 3
CD86 3
monocytes 3
liver 1
MR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 964 100.00 Very High Very High Very High
dexamethasone 24 99.58 Very High Very High Very High
cytokine 449 99.36 Very High Very High Very High
Inflammation 910 97.32 Very High Very High Very High
epidural 28 97.16 Very High Very High Very High
cINOD 24 91.52 High High
backache 28 89.64 High High
palliative 2 85.24 High High
fibrosis 40 84.16 Quite High
cva 48 64.84 Quite High
Disease Link Frequency Relevance Heat
Mitral Valve Insufficiency 72 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 2016 99.84 Very High Very High Very High
Disease 746 99.64 Very High Very High Very High
Congenital Anomalies 211 99.60 Very High Very High Very High
Pressure And Volume Under Development 186 99.04 Very High Very High Very High
Infarction 42 99.00 Very High Very High Very High
Leukemia 140 98.62 Very High Very High Very High
Infection 1977 98.60 Very High Very High Very High
Cancer 679 98.58 Very High Very High Very High
Chorioamnionitis 96 98.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As vena contracta width and regurgitant orifice area have not been validated for a double-orifice valve, these parameters were not included among methods to appraise the severity of MR.


Gene_expression (severity) of MR associated with mitral valve insufficiency
1) Confidence 0.58 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2878966 Disease Relevance 0.67 Pain Relevance 0
Although positive, this study reports results obtained in a non-randomized fashion on a very small sample of patients with functional or degenerative MR selected on the basis of numerous exclusion criteria.
Gene_expression (selected) of MR associated with mitral valve insufficiency
2) Confidence 0.51 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2878966 Disease Relevance 0.77 Pain Relevance 0.09
Interventional procedures and intra-operative MR
Gene_expression (procedures) of MR
3) Confidence 0.51 Published 2010 Journal Anaesthesia Section Body Doc Link PMC2904502 Disease Relevance 0.09 Pain Relevance 0.04
New MR systems
Gene_expression (systems) of MR
4) Confidence 0.51 Published 2010 Journal Anaesthesia Section Body Doc Link PMC2904502 Disease Relevance 0 Pain Relevance 0.08
One pacemaker manufacturer has received a Conformité Européenne (CE) Mark for its second-generation MR safe pacing system.
Gene_expression (generation) of MR
5) Confidence 0.46 Published 2010 Journal Anaesthesia Section Body Doc Link PMC2904502 Disease Relevance 0.09 Pain Relevance 0.03
However, Drukker et al. have shown that although major histocompatibility complex-I expression is low in hESCs, it can be rapidly induced, which could lead to rejection [30].
Gene_expression (expression) of major histocompatibility complex-I
6) Confidence 0.17 Published 2010 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962908 Disease Relevance 0.21 Pain Relevance 0
On the other hand, MDCT cannot yet provide specific qualitative plaque information obtained by MR imaging.
Gene_expression (imaging) of MR in plaque associated with imagery
7) Confidence 0.13 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2801864 Disease Relevance 0.70 Pain Relevance 0.08
Thus, surface expression of human MR on transfected 3T3 cells was sufficient to confer DV binding.


Gene_expression (expression) of MR
8) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.23 Pain Relevance 0.09
In addition to expression on MØ, certain subpopulations of DC, including dermal DC in human skin, express the MR [22], in which case it may be involved in antigen delivery for presentation [23,24].
Gene_expression (express) of MR in skin
9) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.21 Pain Relevance 0
MR is expressed on MØ as well as cells lining venous sinuses in human spleen [25] and is therefore well located to act as a receptor for DV replication in these physiologically relevant target cells.
Gene_expression (expressed) of MR in spleen
10) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.21 Pain Relevance 0
Surface expression of both MR and DC-SIGN is upregulated on MDMØ by IL-4 treatment (Figure 6A and 6B), consistent with previous data for DC-SIGN on human monocytes [20] and for MR on primary mouse MØ [19,21].
Gene_expression (expression) of MR in monocytes
11) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.43 Pain Relevance 0
ELISA wells were coated with semi-purified C6/36-grown DV2 or recombinant soluble E (sE) protein produced in the endothelial kidney cell line 293T (see below for characterisation of this reagent) and probed with the entire extracellular region of the murine MR expressed with an HA tag or recombinant truncated forms of the murine MR with human Fc tags.
Gene_expression (produced) of MR in kidney
12) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.40 Pain Relevance 0.07
Surface expressed MR and DC-SIGN was detected using 10ug/ml 15–2 (Serotec) and 120507 (R&D Systems) monoclonal antibodies, respectively, and was compared with an isotype control (Serotec).
Gene_expression (expressed) of MR
13) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.07 Pain Relevance 0
This, combined with the observation that MDDC express both DC-SIGN and MR [22], and our demonstration that the presence of MR alone is sufficient to confer DV binding to transfected cells, suggest that glycosylation at Asn-67 may be relevant for mediating MR binding, in addition to that of DC-SIGN.
Gene_expression (express) of MR
14) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0 Pain Relevance 0
We also show that pre-treatment of primary human monocytes with Th2 cytokines (IL-4/IL-13), which upregulate MR expression, increases their susceptibility to DV infection in vitro.
Gene_expression (expression) of MR in monocytes associated with infection and cytokine
15) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.53 Pain Relevance 0.08
FACS analysis showed surface MR expression increased over 4-fold following IL-4 treatment of monocytes, corresponding with a similar fold increase in percent infected cells.
Gene_expression (expression) of MR in monocytes
16) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.58 Pain Relevance 0
At this stage the simplest hypothesis that explains the above findings in primary cells expressing both MR and DC-SIGN is that DC-SIGN is required for DV attachment and MR for internalisation.
Gene_expression (expressing) of MR
17) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.56 Pain Relevance 0
It is difficult to assess the relative (and possibly differing) roles of MR and DC-SIGN in DV infection of primary MØ or DC that express both; however, our observation that expression of MR on 3T3 cells confers DV binding suggests that MR can mediate direct recognition of DV by myeloid cells.
Gene_expression (expression) of MR in myeloid cells associated with infection
18) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.63 Pain Relevance 0
While the fold increase in surface MR levels following IL-4 treatment (4.1–fold +/?
Gene_expression (levels) of MR
19) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.50 Pain Relevance 0
A stable NIH3T3 cell line expressing the human MR (3T3.hMR) was a gift from Gordon Brown (University of Cape Town, South Africa) and Philip Taylor (University of Cardiff, UK), made using the protocol described previously [21].
Gene_expression (expressing) of MR
20) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.47 Pain Relevance 0

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