INT177593

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 9.36
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MR1) endoplasmic reticulum (MR1) plasma membrane (MR1)
Anatomy Link Frequency
monocytes 6
bone marrow 4
CD86 2
MR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 222 100.00 Very High Very High Very High
dexamethasone 6 99.82 Very High Very High Very High
cytokine 99 99.58 Very High Very High Very High
Inflammation 8 66.72 Quite High
cINOD 6 32.32 Quite Low
withdrawal 1 21.48 Low Low
addiction 75 5.00 Very Low Very Low Very Low
tolerance 24 5.00 Very Low Very Low Very Low
fibrosis 10 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mitral Valve Insufficiency 36 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 504 99.40 Very High Very High Very High
Infection 378 98.44 Very High Very High Very High
Nephritis 6 97.24 Very High Very High Very High
Cancer 144 96.40 Very High Very High Very High
Necrosis 96 93.24 High High
Disease 162 93.04 High High
Phobia 1 91.08 High High
Infarction 9 85.92 High High
Lymphatic System Cancer 123 85.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As vena contracta width and regurgitant orifice area have not been validated for a double-orifice valve, these parameters were not included among methods to appraise the severity of MR.


Positive_regulation (severity) of Gene_expression (severity) of MR associated with mitral valve insufficiency
1) Confidence 0.43 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2878966 Disease Relevance 0.67 Pain Relevance 0
Interventional procedures and intra-operative MR
Positive_regulation (operative) of Gene_expression (procedures) of MR
2) Confidence 0.38 Published 2010 Journal Anaesthesia Section Body Doc Link PMC2904502 Disease Relevance 0.09 Pain Relevance 0.04
While the fold increase in surface MR levels following IL-4 treatment (4.1–fold +/?
Positive_regulation (increase) of Gene_expression (levels) of MR
3) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.55 Pain Relevance 0
FACS analysis showed surface MR expression increased over 4-fold following IL-4 treatment of monocytes, corresponding with a similar fold increase in percent infected cells.
Positive_regulation (increased) of Gene_expression (expression) of MR in monocytes
4) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.58 Pain Relevance 0
The apparently increasing prevalence of this complication may be due to increasing recognition based on increasing use of MR imaging.
Positive_regulation (increasing) of Gene_expression (imaging) of MR associated with imagery
5) Confidence 0.08 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 1.44 Pain Relevance 0.05
For example, both dynamic contrast-enhanced MR imaging and MR spectroscopy can be acquired in a single diagnostic session to define bone marrow vascular and metabolic characteristics [32].
Positive_regulation (acquired) of Gene_expression (imaging) of MR in bone marrow associated with imagery
6) Confidence 0.08 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0.32 Pain Relevance 0.26
For example, both dynamic contrast-enhanced MR imaging and MR spectroscopy can be acquired in a single diagnostic session to define bone marrow vascular and metabolic characteristics [32].
Positive_regulation (enhanced) of Gene_expression (imaging) of MR in bone marrow associated with imagery
7) Confidence 0.08 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1797072 Disease Relevance 0.36 Pain Relevance 0.25
Histograms show a clear shift in fluorescent intensity indicating DV binding to cells transfected with either human MR or DC-SIGN.
Positive_regulation (transfected) of Gene_expression (transfected) of MR
8) Confidence 0.08 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.14 Pain Relevance 0.07
Surface expression of both MR and DC-SIGN is upregulated on MDMØ by IL-4 treatment (Figure 6A and 6B), consistent with previous data for DC-SIGN on human monocytes [20] and for MR on primary mouse MØ [19,21].
Positive_regulation (upregulated) of Gene_expression (expression) of MR in monocytes
9) Confidence 0.08 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.43 Pain Relevance 0
We also show that pre-treatment of primary human monocytes with Th2 cytokines (IL-4/IL-13), which upregulate MR expression, increases their susceptibility to DV infection in vitro.
Positive_regulation (upregulate) of Gene_expression (expression) of MR in monocytes associated with infection and cytokine
10) Confidence 0.08 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233670 Disease Relevance 0.53 Pain Relevance 0.08
Indeed, we did document lower MR expression on DCs from patients with high serum levels of IFN?.
Positive_regulation (lower) of Gene_expression (expression) of MR
11) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.72 Pain Relevance 0.04
MoDCs cultured in the presence of dexamethasone exhibit upregulated MR expression, a more globally immature phenotype, and higher endocytic activity [33].
Positive_regulation (upregulated) of Gene_expression (expression) of MR associated with dexamethasone
12) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.68 Pain Relevance 0.05
may contribute to aberrant MR expression in the subset of patients with high serum levels.
Spec (may) Positive_regulation (contribute) of Gene_expression (expression) of MR
13) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.96 Pain Relevance 0.03
To determine whether the DC maturation status could account for the diminished FD uptake and MR expression, the association with expression of the maturation marker CD86 was examined (Figure 3a).
Positive_regulation (account) of Gene_expression (expression) of MR in CD86
14) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.66 Pain Relevance 0
We might therefore expect steroid treatment to result in increased MR expression.
Positive_regulation (increased) of Gene_expression (expression) of MR
15) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.61 Pain Relevance 0.05
We might therefore expect steroid treatment to result in increased MR expression.
Positive_regulation (result) of Gene_expression (expression) of MR
16) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 0.61 Pain Relevance 0.05
Neurophysiological factors in functional MR contrast
Positive_regulation (factors) of Gene_expression (contrast) of MR
17) Confidence 0.02 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC419711 Disease Relevance 0 Pain Relevance 0.08
Neurophysiological factors in functional MR contrast
Positive_regulation (functional) of Gene_expression (contrast) of MR
18) Confidence 0.02 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC419711 Disease Relevance 0 Pain Relevance 0.08

General Comments

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