INT177615

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 13.50
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PAX7)
Anatomy Link Frequency
lymph nodes 2
skeletal muscle 2
satellite cells 2
thoracic 1
motoneuron 1
PAX7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 40 96.68 Very High Very High Very High
imagery 241 92.72 High High
backache 21 92.32 High High
abdominal pain 10 79.20 Quite High
Dopamine 9 78.80 Quite High
Inflammation 15 74.88 Quite High
gABA 8 74.56 Quite High
cva 19 71.60 Quite High
Spinal cord 8 67.52 Quite High
positron emission tomography 10 61.56 Quite High
Disease Link Frequency Relevance Heat
Rhabdomyosarcoma 1120 100.00 Very High Very High Very High
Muscular Dystrophy 70 98.80 Very High Very High Very High
Chordoma 131 98.68 Very High Very High Very High
Atelectasis 16 97.68 Very High Very High Very High
Adult Respiratory Distress Syndrome 134 96.88 Very High Very High Very High
Cancer 858 96.60 Very High Very High Very High
Leiomyosarcoma 20 95.84 Very High Very High Very High
Neuroblastoma 2 94.80 High High
Lung Injury 27 93.64 High High
Fibromyalgia 2 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We injected embryos with a control MO, tfap2a MO, tfap2e MO, or tfap2a/e MOs, and at 36 hpf processed them to reveal expression of anti Pax7 IR, a marker of xanthophores [33] (Figure 6A-6C and not shown).
Gene_expression (expression) of Pax7 in xanthophores
1) Confidence 0.65 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2940735 Disease Relevance 0.35 Pain Relevance 0
RT-PCR analysis revealed the expression of M-cadherin, Myf-5, Myogenin, Pax7, MyoD and MRF4 in normal and DMD CD133+CXCR4+CD34- cells after 7 days of co-culture.
Gene_expression (expression) of Pax7 associated with muscular dystrophy
2) Confidence 0.61 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.25 Pain Relevance 0
Finally, RMs followed by moderate PEEP may produce physiologic benefits in patients undergoing upper abdominal, thoracic, or laparoscopic surgery [24,25], and in patients prone to develop a moderate degree of lung injury after surgical procedures [26,27].


Gene_expression (produce) of RMs in thoracic associated with lung injury
3) Confidence 0.52 Published 2004 Journal Crit Care Section Body Doc Link PMC420020 Disease Relevance 0.67 Pain Relevance 0
However, increasing PEEP and RMs prevented alveolar derecruitment, and RMs performed in patients already ventilated with high PEEP had minimal effects on requirements for oxygenation support.
Neg (prevented) Gene_expression (prevented) of RMs
4) Confidence 0.52 Published 2004 Journal Crit Care Section Body Doc Link PMC420020 Disease Relevance 0.16 Pain Relevance 0
For co-immunofluorescent staining for Pax7 and IL-6, Pax7 and IL-6R?
Gene_expression (staining) of Pax7
5) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0
For co-immunofluorescent staining for Pax7 and IL-6, Pax7 and IL-6R?
Gene_expression (staining) of Pax7
6) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0
Data are presented with IL-6+ satellite cells (Pax7+/IL-6+) as a percentage of total Pax7+ cells as well as a percentage of total myonuclei.


Gene_expression (satellite cells) of Pax7 in satellite cells
7) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0
Only nuclei which stained positive for Pax7 and DAPI were counted as satellite cells.
Gene_expression (stained) of Pax7 in satellite cells
8) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0 Pain Relevance 0
To determine whether the neural progenitors have strictly rostral character we next examined the expression of caudal markers (Figures 4F and 4G) such as class I (IRX3, PAX6, PAX7) and class II (OLIG2, NKX2.2, NKX6.1), homeodomein proteins important for motoneuron differentiation [33], [34] and found them highly expressed at D7 and D42.
Spec (examined) Gene_expression (expression) of PAX7 in motoneuron
9) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.23
Histopathology: embryonal RMS
Gene_expression (embryonal) of RMS associated with rhabdomyosarcoma
10) Confidence 0.21 Published 2008 Journal Pediatr Radiol Section Body Doc Link PMC2367394 Disease Relevance 0.71 Pain Relevance 0.15
Pleomorphic RMS, in contrast to embryonal and alveolar RMS, almost exclusively occurs in adults (median age sixth decade), and is therefore not discussed further.
Neg (not) Gene_expression (discussed) of RMS associated with rhabdomyosarcoma
11) Confidence 0.19 Published 2008 Journal Pediatr Radiol Section Body Doc Link PMC2367394 Disease Relevance 1.51 Pain Relevance 0
RMS of the extremities (Figs. 12 and 13) is almost always of alveolar histology, tends to occur in older children and young adults, is often present with positive regional lymph nodes, and has a propensity to metastasize to unusual sites; these negative prognostic factors contribute to the relatively poor prognosis of RMS in this location [51, 52].
Gene_expression (present) of RMS in lymph nodes associated with rhabdomyosarcoma
12) Confidence 0.19 Published 2008 Journal Pediatr Radiol Section Body Doc Link PMC2367394 Disease Relevance 0.66 Pain Relevance 0.07
Fig. 1Embryonal RMS: small cells and primitive spindle-shaped cells resembling the first stages of developing normal skeletal muscle (H&E, original magnification 10×20)Fig. 2Embryonal RMS, spindle-cell type: closely packed spindle cells arranged in perpendicular crossing fascicles giving a leiomyosarcoma-like appearance (H&E, original magnification 10×20)
Gene_expression (2Embryonal) of RMS in skeletal muscle associated with leiomyosarcoma and rhabdomyosarcoma
13) Confidence 0.19 Published 2008 Journal Pediatr Radiol Section Body Doc Link PMC2367394 Disease Relevance 1.46 Pain Relevance 0
RMS of the extremities (Figs. 12 and 13) is almost always of alveolar histology, tends to occur in older children and young adults, is often present with positive regional lymph nodes, and has a propensity to metastasize to unusual sites; these negative prognostic factors contribute to the relatively poor prognosis of RMS in this location [51, 52].
Gene_expression (prognosis) of RMS in lymph nodes associated with rhabdomyosarcoma
14) Confidence 0.19 Published 2008 Journal Pediatr Radiol Section Body Doc Link PMC2367394 Disease Relevance 0.54 Pain Relevance 0.12
Histopathology: embryonal RMS
Gene_expression (embryonal) of RMS associated with rhabdomyosarcoma
15) Confidence 0.19 Published 2008 Journal Pediatr Radiol Section Body Doc Link PMC2367394 Disease Relevance 0.72 Pain Relevance 0.18
Alveolar RMS represents about 20% of all RMS and has two specific translocations with specific fusion transcripts that can be detected by RT-PCR.
Gene_expression (represents) of RMS associated with rhabdomyosarcoma
16) Confidence 0.19 Published 2008 Journal Pediatr Radiol Section Body Doc Link PMC2367394 Disease Relevance 1.28 Pain Relevance 0
Fig. 1Embryonal RMS: small cells and primitive spindle-shaped cells resembling the first stages of developing normal skeletal muscle (H&E, original magnification 10×20)Fig. 2Embryonal RMS, spindle-cell type: closely packed spindle cells arranged in perpendicular crossing fascicles giving a leiomyosarcoma-like appearance (H&E, original magnification 10×20)
Gene_expression (1Embryonal) of RMS in skeletal muscle associated with leiomyosarcoma and rhabdomyosarcoma
17) Confidence 0.19 Published 2008 Journal Pediatr Radiol Section Body Doc Link PMC2367394 Disease Relevance 1.41 Pain Relevance 0
Alveolar RMS represents about 20% of all RMS and has two specific translocations with specific fusion transcripts that can be detected by RT-PCR.
Gene_expression (represents) of RMS associated with rhabdomyosarcoma
18) Confidence 0.19 Published 2008 Journal Pediatr Radiol Section Body Doc Link PMC2367394 Disease Relevance 1.23 Pain Relevance 0
In extremely rare instances RMS can be found in other organs such as the heart, the diaphragm (Fig. 17), the omentum, the urachus and the digestive tract [68–76].
Gene_expression (found) of RMS in digestive tract associated with rhabdomyosarcoma
19) Confidence 0.17 Published 2008 Journal Pediatr Radiol Section Body Doc Link PMC2367394 Disease Relevance 0.85 Pain Relevance 0.24
They include the paired box 7 (PAX7) gene encoding a transcriptional factor expressed in the neural tube which is regulated by notochord specific signals [76], the differentially screening-selected gene aberrant in neuroblastoma (DAN), involved in the negative regulation of cell proliferation [77], the Dishevelled 1 gene (DVL1), a key factor in Wnt signalling expressed in the neural tube [78] and a few genes belonging to the tumour necrosis factor receptor superfamily (TNFRSF-1B, -8, -9, -14), the DNA fragmentation factor (DFF-A and- B) and TP73 [UCSC], all acting in apoptotic pathways.
Gene_expression (expressed) of paired box 7 in notochord associated with necrosis, neuroblastoma, cancer and apoptosis
20) Confidence 0.08 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 1.01 Pain Relevance 0

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