INT177628

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Context Info
Confidence 0.96
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.20
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SERPINA6) extracellular space (SERPINA6) extracellular region (SERPINA6)
Anatomy Link Frequency
lymphocytes 1
cleavage 1
SERPINA6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 60 97.80 Very High Very High Very High
cytokine 35 93.88 High High
antiepileptic Drug 2 79.24 Quite High
dexamethasone 6 62.60 Quite High
Inflammatory response 7 43.84 Quite Low
cva 11 28.80 Quite Low
analgesia 2 26.00 Quite Low
agonist 8 23.48 Low Low
Catecholamine 11 5.00 Very Low Very Low Very Low
medulla 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 68 97.80 Very High Very High Very High
Sepsis 121 77.44 Quite High
Burns 2 75.88 Quite High
Injury 3 75.48 Quite High
Sleep Disorders 6 40.00 Quite Low
Adhesions 1 35.60 Quite Low
Necrosis 13 29.28 Quite Low
Cv General 3 Under Development 11 28.80 Quite Low
Critical Illness 9 20.56 Low Low
Stress 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several factors may be involved and these probably interact: decreased access of cortisol to the inflammatory site secondary to the reduction in circulating CBG; modulation of local cortisol level by a reduction in the cleavage of CBG–cortisol complex (antielastase activity); reduction in the number and affinity of glucocorticoid receptors, shown on lymphocytes treated with different cytokines; and a rise in the conversion of cortisol in inactive cortisone by increased activity of the 11 ?
Protein_catabolism (cleavage) of CBG in lymphocytes associated with inflammation and cytokine
1) Confidence 0.96 Published 2004 Journal Crit Care Section Body Doc Link PMC420022 Disease Relevance 0.53 Pain Relevance 0.17
However, CBG does not alter the activity of this enzyme but is cleaved by it at a single location close to its carboxyl-terminus; this reduces its molecular size by 5 kDa, with concomitant release of more than 80% of CBG-bound cortisol.
Protein_catabolism (cleaved) of CBG
2) Confidence 0.13 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.22 Pain Relevance 0.14
In addition, at the tissue level elastase is crucial for CBG cleavage and thus for cortisol release.
Protein_catabolism (cleavage) of CBG in cleavage
3) Confidence 0.13 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.45 Pain Relevance 0.11

General Comments

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