INT17764

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 4.63
Pain Relevance 9.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) plasma membrane (Drd2) signal transducer activity (Drd2)
Anatomy Link Frequency
shell 2
midbrain 2
forebrain 1
dopamine neurons 1
nucleus accumbens 1
Drd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 140 100.00 Very High Very High Very High
Dopamine 64 100.00 Very High Very High Very High
dopamine receptor 25 100.00 Very High Very High Very High
agonist 10 100.00 Very High Very High Very High
antagonist 9 100.00 Very High Very High Very High
gABA 9 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
Opioid 5 99.90 Very High Very High Very High
Morphine 21 99.84 Very High Very High Very High
Nucleus accumbens 18 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alcohol Addiction 175 100.00 Very High Very High Very High
Stress 20 99.98 Very High Very High Very High
Bordatella Infection 3 99.52 Very High Very High Very High
Depression 6 94.56 High High
Apoptosis 1 94.40 High High
Disease 7 89.68 High High
Heart Rate Under Development 1 88.68 High High
Gliosis 1 83.44 Quite High
Movement Disorders 1 81.12 Quite High
Drug Induced Neurotoxicity 2 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, both fumes caused persistent down-regulation of dopamine D2 receptor (Drd2; 30-40%) and vesicular monoamine transporter 2 (Vmat2; 30-55%) mRNAs in the midbrain.
Negative_regulation (regulation) of dopamine D2 receptor in midbrain associated with dopamine, midbrain and monoamine
1) Confidence 0.42 Published 2010 Journal Arch. Toxicol. Section Abstract Doc Link 20224926 Disease Relevance 0.47 Pain Relevance 0.34
Opioid and D-2 receptor mediated inhibition of forskolin-stimulated cyclic AMP efflux from rat neostriatal slices.
Negative_regulation (inhibition) of D-2 receptor associated with opioid
2) Confidence 0.42 Published 1987 Journal Neuropharmacology Section Title Doc Link 2819763 Disease Relevance 0 Pain Relevance 0.62
Thus a significant over representation of -141C Ins allele in alcoholic subjects in our study may be correlated with decreased DRD2 receptor density in AD patients, which in turn stimulates craving - reward pathway - thereby promoting alcohol dependence.
Negative_regulation (decreased) of DRD2 associated with addiction and alcohol
3) Confidence 0.38 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829542 Disease Relevance 0.80 Pain Relevance 0.45
Biochemical data showing that dopamine inhibits the release of beta-endorphin in the hypothalamus through the dopamine D-2 receptor, suggests a possible mechanism for a blockade of sulpiride-induced hyperdipsia by naloxone.
Negative_regulation (inhibits) of dopamine D-2 receptor in hypothalamus associated with dopamine and narcan
4) Confidence 0.38 Published 1986 Journal Neuropharmacology Section Abstract Doc Link 3748320 Disease Relevance 0 Pain Relevance 0.45
Allele and genotype frequencies of SNPs in DRD2 and their association status with AD are presented in Table 3.
Negative_regulation (presented) of DRD2 associated with addiction
5) Confidence 0.38 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829542 Disease Relevance 0.67 Pain Relevance 0.45
Isolated Flinders Sensitive Line rats have decreased dopamine D2 receptor mRNA.
Negative_regulation (decreased) of D2 receptor associated with dopamine
6) Confidence 0.37 Published 2007 Journal Neuroreport Section Title Doc Link 17558292 Disease Relevance 0.09 Pain Relevance 0.54
Our findings of decreased dopamine D2 receptor levels in socially isolated Flinders Sensitive Line rats suggest that low D2 receptor expression may play a role in pathophysiology of depression.
Negative_regulation (decreased) of D2 receptor associated with dopamine and depression
7) Confidence 0.37 Published 2007 Journal Neuroreport Section Abstract Doc Link 17558292 Disease Relevance 0.18 Pain Relevance 0.58
In the basal ganglia, stress decreased the D2 receptor message in the nucleus accumbens (core and shell) and in the lateral, but not the medial, part of the caudate nucleus, in both control and stressed groups.
Negative_regulation (decreased) of D2 receptor in shell associated with stress and nucleus accumbens
8) Confidence 0.32 Published 1997 Journal Behav Pharmacol Section Abstract Doc Link 9832973 Disease Relevance 0.49 Pain Relevance 0.84
In the midbrain sections, stress decreased the D2 receptor message in the substantia nigra and in the lateral part of the ventral tegmental area (VTA), but not in the medial part of the VTA.
Negative_regulation (decreased) of D2 receptor in midbrain associated with stress, ventral tegmentum, substantia nigra and midbrain
9) Confidence 0.32 Published 1997 Journal Behav Pharmacol Section Abstract Doc Link 9832973 Disease Relevance 0.52 Pain Relevance 0.77
Striatopallidal neurons show a 6-OHDA-induced elevation in their specific expression of messenger RNAs (mRNAs) encoding the D2 dopamine receptor and enkephalin, which is reversed by subsequent continuous treatment with the D2 agonist quinpirole.
Negative_regulation (reversed) of D2 dopamine receptor in neurons associated with dopamine receptor, agonist and enkephalin
10) Confidence 0.31 Published 1990 Journal Science Section Abstract Doc Link 2147780 Disease Relevance 0.26 Pain Relevance 0.63
Effects of intra-medial septum injections of L-arginine, a precursor of nitric oxide, N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase, and sulpiride, a selective antagonist of dopamine D2 receptor on morphine-induced conditioned place preference (CPP) in male Wistar rats were examined.
Negative_regulation (antagonist) of dopamine D2 receptor in medial associated with dopamine, antagonist and morphine
11) Confidence 0.30 Published 2003 Journal Brain Res. Section Abstract Doc Link 12763619 Disease Relevance 0 Pain Relevance 0.57
In rats, a decreased DRD2 density is associated with a preference for ethanol [14], and transient overexpression in the nucleus accumbens attenuated ethanol preference [15].
Negative_regulation (decreased) of DRD2 in nucleus accumbens associated with nucleus accumbens
12) Confidence 0.29 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872348 Disease Relevance 0.37 Pain Relevance 0.38
In conclusion, these results indicate that DA-1 and DA-2 dopamine receptor agonists can be easily discriminated on the basis of their cardiovascular profiles.
Negative_regulation (discriminated) of DA-2 dopamine receptor in DA-1 associated with dopamine receptor and agonist
13) Confidence 0.28 Published 1987 Journal Clin Exp Hypertens A Section Abstract Doc Link 2887315 Disease Relevance 0.20 Pain Relevance 0.21
The effects of D1 or D2 dopamine receptor blockade on zif/268 and preprodynorphin gene expression in rat forebrain following a short-term cocaine binge.
Negative_regulation (blockade) of D2 dopamine receptor in forebrain associated with dopamine receptor and cocaine
14) Confidence 0.25 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8717360 Disease Relevance 0 Pain Relevance 0.57
Caspace 1, D2 dopamine receptor, GABA-A alpha1 subunit, GRIA 1/3/4, Galphai2, PSD-95 and CREB were down-regulated in the NAc shell with morphine administration.
Negative_regulation (down-regulated) of D2 dopamine receptor in shell associated with nucleus accumbens, gaba, dopamine receptor and morphine
15) Confidence 0.21 Published 2004 Journal Neuroscience Section Abstract Doc Link 15183518 Disease Relevance 0.09 Pain Relevance 1.24
We hypothesize that the sensitized responses to cocaine, amphetamine and stress produced by PTX results from a decrease in dopamine D2 and GABAB-mediated inhibitory control of A10 dopamine neurons.
Negative_regulation (decrease) of dopamine D2 in dopamine neurons associated with stress, dopamine and cocaine
16) Confidence 0.02 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1941636 Disease Relevance 0.39 Pain Relevance 0.55
Selective (glybenclamide) and nonselective (tetraethylammonium) K(+)-channel inhibition, guanosine triphosphate-binding protein inactivation (pertussis toxin), and Type 1 and Type 2 dopamine receptor inhibition all failed to alter the attenuating effect of fentanyl on acetylcholine-induced contraction.
Negative_regulation (inhibition) of Type 2 dopamine receptor associated with bordatella infection and dopamine receptor
17) Confidence 0.01 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8610910 Disease Relevance 0.10 Pain Relevance 0.25

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