INT177652

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Context Info
Confidence 0.07
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.92
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Vmn1r51) plasma membrane (Vmn1r51) signal transducer activity (Vmn1r51)
Anatomy Link Frequency
smooth muscle 1
Vmn1r51 (Mus musculus)
Pain Link Frequency Relevance Heat
Catecholamine 14 72.84 Quite High
anesthesia 8 51.68 Quite High
antagonist 6 5.04 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
noradrenaline 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 68 99.70 Very High Very High Very High
Sepsis 26 91.36 High High
Stroke 8 83.48 Quite High
Pressure And Volume Under Development 6 72.00 Quite High
Critical Illness 2 66.68 Quite High
Heart Rate Under Development 10 61.36 Quite High
Stress 2 49.52 Quite Low
Pressure Volume 2 Under Development 8 46.76 Quite Low
Myocardial Infarction 24 45.60 Quite Low
Natriuresis 4 17.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Classically, the effects of vasopressin on the heart were thought to be mediated through the V1R (vascular smooth muscle/calcium-dependent effect) or OTR (endothelial/NO effect).
Positive_regulation (mediated) of V1R in smooth muscle
1) Confidence 0.07 Published 2004 Journal Crit Care Section Body Doc Link PMC420051 Disease Relevance 0.30 Pain Relevance 0.04
Vasopressin can restore vascular tone in refractory vasodilatory shock states due to V1R activation of KATP channels, inhibitory action on NO, and potentiation of endogenous vasoconstrictors.
Positive_regulation (activation) of V1R associated with shock
2) Confidence 0.04 Published 2004 Journal Crit Care Section Body Doc Link PMC420051 Disease Relevance 0.62 Pain Relevance 0.05

General Comments

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