INT17768

Context Info Confidence 0.29 First Reported 1983 Last Reported 1994 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 5 Disease Relevance 2.73 Pain Relevance 0.75

Anatomy Link Frequency plasma 1 Hctq1 (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 4 96.12 Opioid 2 95.84 narcan 6 94.96 tolerance 5 77.20 anesthesia 2 75.24 halothane 1 73.84 Angina 1 60.32 Endogenous opioid 2 43.84 cva 1 31.28

Disease Link Frequency Relevance Heat Hypoxia 16 98.36 Chronic Disease 3 97.40 Anaemia 3 96.64 Rheumatoid Arthritis 4 96.12 Stress 6 88.40 Hypothermia 2 75.00 Hemorrhage 4 72.16 Body Weight 2 69.96 Death 1 69.44 Disease 1 66.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Increased hematocrit is a well-studied adaptation to chronic hypoxia and could be acutely initiated by sympathetically mediated splenic contraction.

Positive_regulation (Increased) of hematocrit associated with hypoxia

1) Confidence 0.29 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8203641 Disease Relevance 0.80 Pain Relevance 0.16

We proposed and evaluated three potential mechanisms of this acute adaptation: 1) increased hematocrit (Hct), 2) protein synthesis, and 3) decreased set point for temperature regulation (set point).

Positive_regulation (increased) of hematocrit

2) Confidence 0.29 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8203641 Disease Relevance 0.72 Pain Relevance 0.14

The increase in hematocrit (Hct) in animals that received saline was significant at the end of cooling and during rewarming.

Positive_regulation (increase) of hematocrit

3) Confidence 0.01 Published 1987 Journal J Cardiovasc Surg (Torino) Section Abstract Doc Link 2444597 Disease Relevance 0.21 Pain Relevance 0.11

Exposure of rats to a simulated altitude of 5,000 m for 1 and 3 d caused increases in hematocrit (Hct) and in hemoglobin (Hb) concentration and a decrease in total plasma volume (TPV) in comparison with sea level control animals.

Positive_regulation (increases) of hematocrit in plasma

4) Confidence 0.00 Published 1983 Journal Aviat Space Environ Med Section Abstract Doc Link 6847573 Disease Relevance 0.26 Pain Relevance 0.14

An increase in hematocrit (Hct) greater than 5 was seen in 4 patients after 4 weeks of therapy.

Positive_regulation (increase) of hematocrit

5) Confidence 0.00 Published 1991 Journal J. Rheumatol. Section Abstract Doc Link 1941817 Disease Relevance 0.74 Pain Relevance 0.19

General Comments

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