INT177684

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Context Info
Confidence 0.05
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.16
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ppap2a) plasma membrane (Ppap2a)
Ppap2a (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 66 99.28 Very High Very High Very High
adenocard 73 97.04 Very High Very High Very High
intrathecal 15 95.68 Very High Very High Very High
Antihyperalgesic 27 89.44 High High
antiallodynic 24 87.76 High High
addiction 3 76.56 Quite High
withdrawal 21 51.20 Quite High
Inflammation 27 50.00 Quite Low
Spinal cord 28 37.56 Quite Low
antinociception 30 31.04 Quite Low
Disease Link Frequency Relevance Heat
Infection 5 98.46 Very High Very High Very High
Nociception 34 50.00 Quite Low
INFLAMMATION 31 50.00 Quite Low
Reprotox - General 1 1 45.04 Quite Low
Necrosis 6 25.64 Quite Low
Cancer 6 25.28 Quite Low
Paralysis 12 20.32 Low Low
Pain 26 19.76 Low Low
Sleep Disorders 6 19.28 Low Low
Inflammatory Pain 18 12.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recombinant mPAP dephosphorylates purine nucleotides in a pH-dependent manner
mPAP Binding (Recombinant) of
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.06 Pain Relevance 0.08
Recombinant mPAP has long-lasting antinociceptive properties
mPAP Binding (Recombinant) of associated with antinociceptive
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0 Pain Relevance 0.35
Recombinant mPAP was kept at 4°C for short-term (1–2 months) use and at ?
mPAP Binding (Recombinant) of
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0 Pain Relevance 0
or IL-6 concentrations or signs of infection, and all of them responded physiologically to the endotoxin infusion with a doubling of the MPAP.
MPAP Binding (doubling) of associated with infection
4) Confidence 0.03 Published 2004 Journal Crit Care Section Body Doc Link PMC420063 Disease Relevance 0.10 Pain Relevance 0
This resulted in a high-titer antibody that recognized secretory mPAP protein in enzyme-linked immunosorbent assays (data not shown) and on western blots (Figure 1A).
mPAP protein Binding (recognized) of
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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