INT177759

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 51
Total Number 52
Disease Relevance 31.81
Pain Relevance 7.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
macrophage 1
monocytes 1
hepatocytes 1
superior 1
IFN1@ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 649 100.00 Very High Very High Very High
Inflammation 375 100.00 Very High Very High Very High
Arthritis 344 99.82 Very High Very High Very High
agonist 52 99.80 Very High Very High Very High
Cannabinoid 13 99.40 Very High Very High Very High
Central nervous system 298 96.56 Very High Very High Very High
Potency 37 96.16 Very High Very High Very High
rheumatoid arthritis 128 95.28 Very High Very High Very High
Endocannabinoid 12 91.52 High High
chemokine 87 86.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 396 100.00 Very High Very High Very High
Leishmaniasis 67 99.88 Very High Very High Very High
Glioma 71 99.84 Very High Very High Very High
Arthritis 376 99.82 Very High Very High Very High
Conjunctivitis 15 99.54 Very High Very High Very High
Eczema 239 99.48 Very High Very High Very High
Keloid Scars 18 99.36 Very High Very High Very High
Syndrome 131 99.34 Very High Very High Very High
Targeted Disruption 73 98.98 Very High Very High Very High
Parasitemia 61 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, and a statistically significant reduction in IFN-?
Negative_regulation (reduction) of IFN
1) Confidence 0.57 Published 2007 Journal Virol J Section Body Doc Link PMC1899484 Disease Relevance 0.29 Pain Relevance 0.29
Subjects with scarring trachoma have shown to produce reduced IFN-?
Negative_regulation (reduced) of IFN associated with conjunctivitis and keloid scars
2) Confidence 0.57 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2695819 Disease Relevance 2.23 Pain Relevance 0.11
The glucocorticoid receptor in rat hepatocytes is activated by UDCA in a ligand-independent way, whereas suppression of IFN-?
Negative_regulation (suppression) of IFN in hepatocytes
3) Confidence 0.57 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.88 Pain Relevance 0.36
This is observed by a significant reduction of IFN-?
Negative_regulation (reduction) of IFN
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993957 Disease Relevance 0.16 Pain Relevance 0.05
Bulk analysis of activated KO CD4+ or CD8+ splenocytes by flow cytometry showed reductions in IL-2 and IFN-?
Negative_regulation (reductions) of IFN associated with targeted disruption
5) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.71 Pain Relevance 0.12
The reduction in cytotoxic activity was explained by a reduction in IFN-?
Negative_regulation (reduction) of IFN
6) Confidence 0.57 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 0.80 Pain Relevance 0.13
and decreases macrophage production of IL-12 causing a decline in cytotoxic activity and IFN-?
Negative_regulation (decline) of IFN in macrophage
7) Confidence 0.42 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 0.99 Pain Relevance 0.17
production was significantly increased as reflected by a decreased IL-17/IFN-?
Negative_regulation (decreased) of IFN
8) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0 Pain Relevance 0.08
-IFN has been shown to be down-regulated by p-STAT-3 [15] and accordingly ?
Negative_regulation (down-regulated) of IFN
9) Confidence 0.42 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.45 Pain Relevance 0.07
I.n. immunization with subunit vaccine resulted in lower numbers of IL-4-producing cells but substantially higher numbers of IFN-?
Negative_regulation (numbers) of IFN associated with immunization
10) Confidence 0.42 Published 2010 Journal AAPS J Section Body Doc Link PMC2844513 Disease Relevance 1.15 Pain Relevance 0.06
Therefore, this FX cream is expected as a useful skin care agent for atopic dry skin colonized by SA.3,4 Recently, we also found that AD-like lesions in DS-Nh of AD model mouse mice were significantly improved together with a decrease in number of SA detected from these lesions by treatment with the bamboo leaf extract cream having the antibacterial, viral and mycotic activity.5 This improvement effect was also observed together with a decrease of the increased serum IgE levels and IFN-?
Negative_regulation (decrease) of IFN in leaf associated with bacterial respiratory disease and eczema
11) Confidence 0.42 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.70 Pain Relevance 0.03
In CT-positive women with fertility disorders, significantly (P < 0.05) lower number of IFN-?
Negative_regulation (number) of IFN associated with chlamydia infection
12) Confidence 0.42 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2695819 Disease Relevance 0.82 Pain Relevance 0.03
Therefore, Gourley et al. has suggested that the decrease in the granuloma size in the CIITA-/-I-E-transgenic mice might be due to the elevated IL-4 production, not a decrease in the IFN-?
Negative_regulation (decrease) of IFN associated with targeted disruption and granuloma
13) Confidence 0.42 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.77 Pain Relevance 0
Therefore, from these results a specific profile for NK resistant oral tumors emerged which demonstrated increased GM-CSF, IL-6 and IL-8 secretion in the context of decreased IFN-?
Negative_regulation (decreased) of IFN associated with cancer
14) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.58 Pain Relevance 0.06
-IFN levels have been shown to be decreased in glioma patient PBMCs [24].
Negative_regulation (decreased) of IFN associated with glioma
15) Confidence 0.42 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.50 Pain Relevance 0.10
The latter three cytokines are recognized as very potent inhibitors of IFN-?
Negative_regulation (inhibitors) of IFN associated with cytokine
16) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0.45 Pain Relevance 0.35
Higher numbers of IFN-?
Negative_regulation (numbers) of IFN
17) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2646145 Disease Relevance 0.22 Pain Relevance 0.04
The deficiency of either IFN-?
Negative_regulation (deficiency) of IFN
18) Confidence 0.42 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.54 Pain Relevance 0.21
A potential role for mTOR was identified as pre-treatment of the cells with rapamycin attenuated the IFN-?
Negative_regulation (attenuated) of IFN
19) Confidence 0.42 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.40 Pain Relevance 0.05
Using RNAse protection assay and flow cytometry, it was observed that simvastatin, in a dose dependent fashion, reduced IFN-?
Negative_regulation (reduced) of IFN
20) Confidence 0.42 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC425594 Disease Relevance 0.41 Pain Relevance 0.03

General Comments

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