INT177773

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.89
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PSEN1) Golgi apparatus (PSEN1) endoplasmic reticulum (PSEN1)
embryo development (PSEN1) peptidase activity (PSEN1) cell death (PSEN1)
Anatomy Link Frequency
germ cells 1
fibroblasts 1
PSEN1 (Homo sapiens)
PSEN1 - A246E (1)
Pain Link Frequency Relevance Heat
Serotonin 2 92.92 High High
Central nervous system 40 83.28 Quite High
Neuropeptide 7 80.56 Quite High
bradykinin 75 53.36 Quite High
Inflammation 24 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 224 100.00 Very High Very High Very High
Ovarian Cancer 3 65.56 Quite High
Cyst 5 61.76 Quite High
Alzheimer's Dementia 17 57.52 Quite High
Aging 157 50.00 Quite Low
Stress 107 50.00 Quite Low
Down Syndrome 17 27.96 Quite Low
Neurological Disease 2 16.36 Low Low
Apoptosis 41 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mammals, presenilins 1 and 2 (PSEN1 and PSEN2), which are processing enzymes of APP and the ApoE4 protein, are implicated in the etiology of AD (Walsh and Selkoe, 2004; Selkoe and Wolfe, 2007).
Localization (implicated) of presenilin associated with disease
1) Confidence 0.73 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2910937 Disease Relevance 0.16 Pain Relevance 0.17
This compares with PS-1 A246E and L286V mutations whose age of AD onset is generally later than 40 and whose fibroblasts secrete 2-3-fold more A?
Localization (secrete) of PS-1 A246E (A246E) in fibroblasts associated with disease
2) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.45 Pain Relevance 0.03
-secretase site, PS1-D257TG has less effect on the elevation of A?
Localization (secretase) of PS1-D257TG
3) Confidence 0.61 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0
In the cortex, the putative germ cells showed a translocation of nuclear PS1 immunoexpression to cytoplasmic staining, suggesting termination of the meiotic prophase, and an association with cortical vasculature showing minute amounts of PS1 immunoexpression in adjacent endothelial cells (panel F).
Localization (translocation) of PS1 in germ cells
4) Confidence 0.49 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC420494 Disease Relevance 0.13 Pain Relevance 0
In mammals, presenilins 1 and 2 (PSEN1 and PSEN2), which are processing enzymes of APP and the ApoE4 protein, are implicated in the etiology of AD (Walsh and Selkoe, 2004; Selkoe and Wolfe, 2007).
Localization (implicated) of PSEN1 associated with disease
5) Confidence 0.38 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2910937 Disease Relevance 0.16 Pain Relevance 0.16

General Comments

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