INT177778

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2010
Negated 8
Speculated 0
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 16.42
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (SQLE) oxidoreductase activity (SQLE) endoplasmic reticulum (SQLE)
Anatomy Link Frequency
germ cells 1
fibroblasts 1
oocyte 1
nasal mucosa 1
body 1
SQLE (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 189 99.60 Very High Very High Very High
Inflammation 232 92.80 High High
Inflammatory mediators 30 91.16 High High
Fibrositis 12 51.84 Quite High
Arthritis 18 32.60 Quite Low
pain pelvic 5 20.72 Low Low
Pain 3 16.40 Low Low
Neuropathic pain 2 11.80 Low Low
depression 2 11.08 Low Low
cINOD 52 10.36 Low Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 280 99.68 Very High Very High Very High
Rheumatoid Arthritis 189 99.60 Very High Very High Very High
Sprains And Strains 105 99.56 Very High Very High Very High
Syndrome 75 99.44 Very High Very High Very High
Chronic Sinusitis 825 99.32 Very High Very High Very High
Cancer 160 98.28 Very High Very High Very High
Disease Progression 15 96.76 Very High Very High Very High
Disease 192 96.60 Very High Very High Very High
Polyps 90 95.92 Very High Very High Very High
INFLAMMATION 266 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SQLE overexpression was found in high-risk ER+ stage I/II BCs [60] but SQLE mRNA overexpression was not different in ER+ and ER- ERBB2-amplified tumors.
Gene_expression (overexpression) of SQLE associated with cancer
1) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.91 Pain Relevance 0
Among the 2 genes upregulated in ERBB2-amplified IBCs compared to ERBB2-amplified NIBCs, SQLE (8q24.13) was gained or amplified in IBCs but not in NIBCs while RSF1 (11q13.5) was not targeted by CNA in the two populations.
Neg (not) Gene_expression (targeted) of SQLE
2) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.36 Pain Relevance 0.15
It should be noted that out of the 9 CRSwNP patients where no se could be detected, 1, 4 and 4 were observed in NP1, NP2 and NP3, respectively.
Neg (no) Gene_expression (detected) of se
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.71 Pain Relevance 0.05
At least one se was detected in 79/93 patients (84.9%), including 46/55 with CRSwNP (83.6%), 15/16 with CRSsNP (93.7%) and 18/22 controls (81.2%) (Table1).
Gene_expression (detected) of se
4) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.32 Pain Relevance 0
Along similar lines, there was no significant difference in the overall quantity of se detected in NP1 and NP2 patients groups.
Neg (no) Gene_expression (detected) of se
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.36 Pain Relevance 0.16
It should be noted that out of the 9 CRSwNP patients where no se was detected, 1 patient was in NP1, 4 were in NP2 and 4 were NP3 subgroups.
Neg (no) Gene_expression (detected) of se
6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.33 Pain Relevance 0.16
Prevalence of Zn and Se deficiency of the HIV infected individuals and healthy persons also are shown in Table 4.
Gene_expression (deficiency) of Se associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.09 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2613901 Disease Relevance 1.15 Pain Relevance 0
Serum Zn and Se levels were measured using atomic absorption spectrophotometer (Atomic absorption spectrophotometer Shimadzu, AA-680, Japan).
Gene_expression (levels) of Se
8) Confidence 0.09 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2613901 Disease Relevance 0.86 Pain Relevance 0
In another hand we know that serum Zn and Se levels may not be the best indicator of total stores for these trace elements in the body and cellular concentrations or related enzymes activity may be more reliable.
Gene_expression (levels) of Se in body
9) Confidence 0.09 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2613901 Disease Relevance 1.11 Pain Relevance 0
There was no significant difference in the quantity of all se detected in NP1 and NP2 patients groups.
Gene_expression (detected) of se
10) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.57 Pain Relevance 0.06
Finally, the frequency of all other individual se was similar between groups, suggesting that the correlation between the presence of any particular se and the severity of CRS remains unclear.
Gene_expression (presence) of se associated with chronic sinusitis
11) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.24 Pain Relevance 0
There were 9 CRSwNP patients in whom no se was detected.
Neg (no) Gene_expression (detected) of se
12) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.29 Pain Relevance 0.07
Overall, there were 318 se detected in the 55 patients with CRSwNP, 85 detected in the 16 patients with CRSsNP and 125 detected in the 22 controls.
Gene_expression (detected) of se
13) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.19 Pain Relevance 0
Interestingly, only 71 of 214 patients suffering from CRS were carrying SA and only 61 had se present in the SA strains.
Gene_expression (present) of se associated with chronic sinusitis and sprains and strains
14) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.67 Pain Relevance 0.03
Our study focused on exotoxin genes of SA carriers: we did neither find any correlation between the presence of any particular se, nor large numbers of se, and CRS, with or without NP.
Gene_expression (presence) of se associated with chronic sinusitis
15) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.79 Pain Relevance 0
Among the 3 patients with Widal syndrome in the NP3 group, 2 had no detectable se, suggesting that this pathological entity is not strictly dependent on the presence of se.
Neg (no) Gene_expression (detectable) of se associated with syndrome
16) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.79 Pain Relevance 0.03
The presence of activated T lymphocytes, within the nasal mucosa of patients with CRSwNP, and IgE directed against SE has been suggested as evidence for a role for exotoxins in the pathogenesis of this disease.
Gene_expression (directed) of SE in nasal mucosa associated with disease
17) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.74 Pain Relevance 0.05
Using the Mann Whitney U Test, there was no statistically significant difference between the overall numbers of se detected in the CRSwNP and control groups (p?
Gene_expression (numbers) of se
18) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.21 Pain Relevance 0
The goals of this study were 1) to evaluate nutritional status of newly diagnosed Iranian HIV-infected individuals and 2) to compare the serum Zn and Se levels in these patients with those of healthy individuals.


Gene_expression (levels) of Se associated with acquired immune deficiency syndrome or hiv infection
19) Confidence 0.08 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2613901 Disease Relevance 1.24 Pain Relevance 0
Thirdly, there was no difference between these groups in the overall quantities of se detected.
Gene_expression (detected) of se
20) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.20 Pain Relevance 0

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