INT17779

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Context Info
Confidence 0.40
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.50
Pain Relevance 6.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
liver 2
leukocyte 1
central nervous system 1
Got1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 10 100.00 Very High Very High Very High
methotrexate 8 100.00 Very High Very High Very High
agonist 2 99.78 Very High Very High Very High
GABA receptor 1 99.60 Very High Very High Very High
Paracetamol 56 99.50 Very High Very High Very High
anticonvulsant 1 99.34 Very High Very High Very High
Antinociceptive 2 96.62 Very High Very High Very High
Morphine 9 96.60 Very High Very High Very High
Glutamate 6 96.00 Very High Very High Very High
GABAergic 4 93.92 High High
Disease Link Frequency Relevance Heat
Death 2 99.74 Very High Very High Very High
Injury 10 99.38 Very High Very High Very High
Necrosis 3 98.64 Very High Very High Very High
Apoptosis 5 96.68 Very High Very High Very High
Hepatitis 8 93.32 High High
Disease 4 91.12 High High
Hepatotoxicity 7 90.08 High High
Acute Liver Failure 9 89.68 High High
INFLAMMATION 2 87.92 High High
Hepatitis C Virus Infection 102 85.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The elevated serum transaminase levels and liver lesions were reduced by kopsinine.
Negative_regulation (reduced) of serum transaminase in liver
1) Confidence 0.40 Published 1989 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 2816405 Disease Relevance 0.17 Pain Relevance 0.10
If methotrexate is administered in conjunction with either nicotinamide or methionine, the rise in the death rate and in GOT and GPT activities associated with methotrexate application is markedly reduced.
Negative_regulation (reduced) of GOT associated with methotrexate and death
2) Confidence 0.40 Published 1999 Journal Gen. Pharmacol. Section Abstract Doc Link 10461859 Disease Relevance 0.35 Pain Relevance 0.49
Prazosin (15 mg/kg) pre-treatment provided protection against APAP-induced hepatic injury as evidenced by a significant decrease in serum transaminase (ALT) levels after 5h (p<0.05).
Negative_regulation (decrease) of transaminase associated with paracetamol and injury
3) Confidence 0.27 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 16054166 Disease Relevance 0.25 Pain Relevance 0.80
RESULTS: Ketoconazole significantly decreased mortality and transaminase levels when given to mice either 30 min before or 2 h after AAP.
Negative_regulation (decreased) of transaminase
4) Confidence 0.25 Published 1995 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 7496865 Disease Relevance 0.07 Pain Relevance 0
When comparing antinociceptive responses at maximally effective doses it was also found that the SKF compounds were substantially more efficacious than direct-acting GABA receptor agonists or a GABA transaminase inhibitor.
Negative_regulation (inhibitor) of transaminase associated with gaba, gaba receptor, agonist and antinociceptive
5) Confidence 0.23 Published 1985 Journal Life Sci. Section Abstract Doc Link 4058259 Disease Relevance 0 Pain Relevance 0.80
Valproate, a clinically widely used anticonvulsant and mood stabilizer, can mainly inhibit gamma-aminobutyric acid (GABA) transaminase and activate glutamic acid decarboxylase, which result in decrease in the degradation and increase in the synthesis of GABA, and then the elevation of extracellular GABA in the central nervous system.
Negative_regulation (inhibit) of transaminase in central nervous system associated with gaba, central nervous system and anticonvulsant
6) Confidence 0.23 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15196792 Disease Relevance 0 Pain Relevance 0.78
The acetaminophen-induced release of both GOT and GPT from injured liver cells could be inhibited in a dose-dependent manner, when mice were injected additionally either with increasing amounts (from (25 mg/kg to 100 mg/kg i.p.) of the PARP-inhibitor nicotinamide, with increasing amounts (from 25 mg/kg to 100 mg/kg i.p.) of the antioxidant N-acetylcysteine, or with increasing amounts (from 50 mg/kg to 300 mg/kg i.p.) of the amino acid L-methionine. 4.
Negative_regulation (inhibited) of GOT in liver associated with paracetamol
7) Confidence 0.19 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9013204 Disease Relevance 0.25 Pain Relevance 0.51
All IFN-gamma-deficient mice survived with reduced serum transaminase elevation and attenuated hepatic necrosis, leukocyte infiltration, and hepatocyte apoptosis.
Negative_regulation (reduced) of serum transaminase in leukocyte associated with necrosis and apoptosis
8) Confidence 0.16 Published 2002 Journal FASEB J. Section Abstract Doc Link 12153990 Disease Relevance 1.05 Pain Relevance 0.24
IL-1 alpha had a significant protective effect if given 2 or more hours (up to 24 hours) before AAP; it significantly reduced mortality of mice and decreased serum transaminase level.
Negative_regulation (decreased) of transaminase associated with paracetamol
9) Confidence 0.12 Published 1993 Journal Cytokine Section Abstract Doc Link 8218930 Disease Relevance 0.17 Pain Relevance 0.44
There were significant reductions in serum transaminase and SICD activities in the APAP- + ascorbate ester-treated animals as compared to APAP-positive controls.
Negative_regulation (reductions) of serum transaminase associated with paracetamol
10) Confidence 0.05 Published 1991 Journal J. Biochem. Toxicol. Section Abstract Doc Link 1941904 Disease Relevance 0.09 Pain Relevance 1.02
MnTBAP preventively and curatively administered significantly improved survival times, and dramatically reduced serum transaminase activity levels and parenchymal lesions in APAP-intoxicated mice.
Negative_regulation (reduced) of serum transaminase associated with paracetamol
11) Confidence 0.04 Published 2001 Journal Hepatology Section Abstract Doc Link 11343246 Disease Relevance 0.90 Pain Relevance 0.88
According to the clinical investigation, the three patients displayed lower viral copies (3.62×104, 5.38×105, and 2.81×104 copies/ml) and mild alanine transaminase levels (96, 102, and 132 IU/ml) in the sera before antiviral treatments, compared with the mean viral load of 3.32×106 copies/ml and transaminase level of 115 IU/ml respectively of the total recruited patients.
Negative_regulation (/) of transaminase
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 0.20 Pain Relevance 0.03

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