INT177831

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 21.37
Pain Relevance 8.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HDAC1) nucleoplasm (HDAC1) nucleolus (HDAC1)
nucleus (HDAC1) enzyme binding (HDAC1) transcription factor binding (HDAC1)
Anatomy Link Frequency
retina 1
synovial cells 1
HeLa 1
band 1
fibroblasts 1
HDAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1186 99.84 Very High Very High Very High
Osteoarthritis 576 99.48 Very High Very High Very High
Inflammation 417 98.44 Very High Very High Very High
Arthritis 82 81.36 Quite High
methotrexate 64 78.88 Quite High
cINOD 77 75.76 Quite High
aspirin 31 75.08 Quite High
cytokine 82 58.88 Quite High
Inflammatory mediators 32 53.52 Quite High
headache 9 52.80 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 161 99.92 Very High Very High Very High
Rheumatoid Arthritis 1186 99.84 Very High Very High Very High
Cancer 395 99.84 Very High Very High Very High
Decubitus Ulcers 5 99.60 Very High Very High Very High
Frailty 610 99.48 Very High Very High Very High
INFLAMMATION 508 98.44 Very High Very High Very High
Coma 13 97.04 Very High Very High Very High
Neurodegenerative Disease 4 96.64 Very High Very High Very High
Disease 192 93.60 High High
Cirrhosis 7 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In spite of the continuing nursing care since the start of hospitalization, bedsores on the trochanters appeared on HD19.
Gene_expression (appeared) of HD1 in trochanters associated with decubitus ulcers
1) Confidence 0.65 Published 2006 Journal Filaria J Section Body Doc Link PMC1471781 Disease Relevance 0.86 Pain Relevance 0
VPA, as well as other HDAC inhibitors (HDACi), is able to alter expression of many genes.
Gene_expression (expression) of HDACi
2) Confidence 0.65 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.36 Pain Relevance 0.11
Second, they demonstrated lower levels of HDAC1, and HDAC2 protein in RA synovium than in OA by Western blotting of whole cell lysates, with ?
Gene_expression (levels) of HDAC1 in synovium associated with rheumatoid arthritis and osteoarthritis
3) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.58 Pain Relevance 0.72
The level of nuclear HDAC1 protein expression was higher in RA synovial tissue compared with OA synovial tissue (Figure 4a).
Gene_expression (expression) of HDAC1 associated with rheumatoid arthritis and osteoarthritis
4) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.15 Pain Relevance 0.58
stimulation, suggesting that HDAC1 overexpression might be associated with the enhanced inflammatory reaction.
Gene_expression (overexpression) of HDAC1 associated with inflammation
5) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.08 Pain Relevance 0.43
In RASFs, only HDAC1 mRNA and HDAC1 protein expression among class I HDACs increased through the time courses after TNF?
Gene_expression (expression) of HDAC1 mRNA
6) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.09 Pain Relevance 0.44
Western blot analysis of class I HDACs in synovial tissues showed that the expression of HDAC1 protein was significantly increased in RA lesions, compared with OA lesions.
Gene_expression (expression) of HDAC1 associated with rheumatoid arthritis and osteoarthritis
7) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.13 Pain Relevance 0.46
In RASFs, only HDAC1 mRNA and HDAC1 protein expression among class I HDACs increased through the time courses after TNF?
Gene_expression (expression) of HDAC1
8) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.08 Pain Relevance 0.44
The level of expression of HDAC1 by normalizing to the band density of nuclear membrane protein lamin A was significantly higher in RA than OA synovial tissue (P = 0.0495) (Figure 4b) (see Additional file 1).


Gene_expression (expression) of HDAC1 in band associated with rheumatoid arthritis and osteoarthritis
9) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.06 Pain Relevance 0.53
The expression of HDAC1 in RASFs (n = 3) was increased after TNF?
Gene_expression (expression) of HDAC1
10) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.46 Pain Relevance 0.23
Most recently, Horiuchi et al. also showed HDAC1 is overexpressed in RASF compared to OA synovial fibroblasts [41].
Gene_expression (overexpressed) of HDAC1 in fibroblasts associated with osteoarthritis
11) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.24 Pain Relevance 0.36
MeCP2, EZH2 and HDAC1 were more expressed in HCT116 than HT29 cells, thus inversely correlating with PPAR?
Gene_expression (expressed) of HDAC1
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.38 Pain Relevance 0
The nuclear HDAC1 protein expression in RASFs (n = 3) was elevated compared to other class I HDACs (HDAC2, HDAC3, HDAC8) after TNF?
Gene_expression (expression) of HDAC1
13) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.39 Pain Relevance 0.12
significantly increased the nuclear HDAC activity and HDAC1 mRNA expression at 24 hours and HDAC1 protein expression at 48 hours in RASFs.


Gene_expression (expression) of HDAC1 mRNA
14) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945023 Disease Relevance 1.45 Pain Relevance 0.59
Our results showed nuclear HDAC activity and expression of HDAC1 were significantly higher in RA than in OA synovial tissues, and they were upregulated by TNF?
Gene_expression (expression) of HDAC1 associated with rheumatoid arthritis and osteoarthritis
15) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945023 Disease Relevance 1.20 Pain Relevance 0.47
RA synovial tissues expressed high levels of HDAC1 compared to OA (P = 0.018), and normal controls (Figure 3a).
Gene_expression (expressed) of HDAC1 associated with rheumatoid arthritis and osteoarthritis
16) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.48 Pain Relevance 0.74
The mRNA expression of HDAC1 in RA synovial tissue was higher than in OA and normal controls, and showed positive correlation with TNF?
Gene_expression (expression) of HDAC1 associated with rheumatoid arthritis and osteoarthritis
17) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945023 Disease Relevance 1.61 Pain Relevance 0.65
significantly increased the nuclear HDAC activity and HDAC1 mRNA expression at 24 hours and HDAC1 protein expression at 48 hours in RASFs.


Gene_expression (expression) of HDAC1
18) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945023 Disease Relevance 1.34 Pain Relevance 0.53
Among HDACs, increased activity and expression of nuclear HDAC1 in synovial cells might play a role in RA inflammation.


Gene_expression (expression) of HDAC1 in synovial cells associated with inflammation and rheumatoid arthritis
19) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.60 Pain Relevance 0.75
Simultaneously, Phiel et al., after demonstrating VPA's ability to activate multiple promoter-regulated transcription, assayed HDAC1 activity in the presence of VPA in HeLa cells that over-expressed HDAC1.
Gene_expression (expressed) of HDAC1 in HeLa
20) Confidence 0.36 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.12 Pain Relevance 0

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