INT177841

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.64
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CCNA2) mitosis (CCNA2) nucleus (CCNA2)
cell division (CCNA2) cytoplasm (CCNA2)
CCNA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 1460 99.62 Very High Very High Very High
Central nervous system 50 49.28 Quite Low
monoamine 15 5.00 Very Low Very Low Very Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
Neurobehavioral 10 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
sodium channel 5 5.00 Very Low Very Low Very Low
gABA 5 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 1 92.20 High High
Apoptosis 26 92.08 High High
Cytomegalovirus Infection 20 91.48 High High
Cancer 9 75.68 Quite High
Colon Cancer 40 71.52 Quite High
Intellectual Impairment 5 40.72 Quite Low
Necrosis 5 38.52 Quite Low
Neurodegenerative Disease 110 37.24 Quite Low
Cocaine Dependence 35 32.52 Quite Low
Congenital Anomalies 25 30.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of AF5 cells with a cyclin A2 expression vector (a piece of DNA that directs the production of cyclin A2) counteracted the down-regulation of cyclin A2 and restored AF5 proliferation in the presence of cocaine.
Gene_expression (production) of cyclin A2 associated with cocaine
1) Confidence 0.50 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504032 Disease Relevance 0 Pain Relevance 0.37
Treatment of AF5 cells with a cyclin A2 expression vector (a piece of DNA that directs the production of cyclin A2) counteracted the down-regulation of cyclin A2 and restored AF5 proliferation in the presence of cocaine.
Gene_expression (expression) of cyclin A2 associated with cocaine
2) Confidence 0.50 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504032 Disease Relevance 0 Pain Relevance 0.34
Quantitative real-time RT-PCR showed that cyclin A2 mRNA was decreased as early as 6 h after 10 or 100 ?
Gene_expression (mRNA) of cyclin A2
3) Confidence 0.43 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.22 Pain Relevance 0.43
The decrease in cyclin A2 expression by 10 or 100 ?
Gene_expression (expression) of cyclin A2
4) Confidence 0.38 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0 Pain Relevance 0.49
Next, the researchers showed that cocaine-treated AF5 cells made much less cyclin A2, a protein that controls the G1-to-S transition, than untreated cells.
Gene_expression (made) of cyclin A2 associated with cocaine
5) Confidence 0.38 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504032 Disease Relevance 0 Pain Relevance 0.34
In response to exposure to the low concentration of curcumin for 12 hours expression of cyclin H was downregulated (1.5-fold) and expression of cyclin A2 was upregulated (1.7-fold).
Gene_expression (expression) of cyclin A2
6) Confidence 0.09 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.41 Pain Relevance 0

General Comments

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