INT177842

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Context Info
Confidence 0.31
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.65
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HDAC1) nucleoplasm (HDAC1) nucleolus (HDAC1)
nucleus (HDAC1) enzyme binding (HDAC1) transcription factor binding (HDAC1)
Anatomy Link Frequency
HeLa 1
T cells 1
HDAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anticonvulsant 2 99.68 Very High Very High Very High
Osteoarthritis 36 98.88 Very High Very High Very High
rheumatoid arthritis 74 91.64 High High
Bioavailability 6 86.92 High High
Inflammation 31 73.92 Quite High
antagonist 4 59.48 Quite High
Potency 5 35.20 Quite Low
methotrexate 4 28.24 Quite Low
Arthritis 6 26.28 Quite Low
cINOD 11 25.12 Quite Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 32 99.20 Very High Very High Very High
Repression 18 99.06 Very High Very High Very High
Frailty 38 98.88 Very High Very High Very High
Apoptosis 57 94.44 High High
Cancer 173 93.28 High High
Rheumatoid Arthritis 75 91.64 High High
Colon Cancer 149 89.12 High High
Cv General 2 Under Development 1 84.84 Quite High
Anorexia 7 84.28 Quite High
Volume Depletion And Dehydration 2 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differently, exposure to AZA and TSA causes replacement with active chromatin marks such as H3K9Ac and H3K4me3, accompanied by a complete loss of HDAC1 and MeCP2.
Negative_regulation (loss) of HDAC1
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0.42 Pain Relevance 0
In HDAC enzyme activity assay, the benzamide analogs CI994, MS275 and MGCD0103 are partial inhibitors of HeLa nuclear extract HDACs activity, as they show full and potent inhibition of HDAC1 and 3 isoenzymes, but no inhibition of HDAC6 occurs and high ?
Negative_regulation (inhibition) of HDAC1 in HeLa
2) Confidence 0.27 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.58 Pain Relevance 0.04
Histone deacetylase (HDAC1) was downregulated 1.7-fold by the high concentration of curcumin after 24 hours.
Negative_regulation (downregulated) of HDAC1
3) Confidence 0.27 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.32 Pain Relevance 0
Knockdown of HDAC1 and HDAC2 by siRNA resulted in increased expression of p16, p21, and p53, and decreased cell counts and cell proliferation, and increased apoptosis in RASF.
Negative_regulation (Knockdown) of HDAC1 associated with apoptosis
4) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.24 Pain Relevance 0.36
Histone deacetylase 1 (HDAC1), which mediates chromatin remodeling, has been implicated in the repression of HIV gene expression in infected cells, and inhibition of HDAC1 by the anticonvulsant valporic acid (VPA) results in reactivation of HIV-1 replication in latently infected T cells [32].
Negative_regulation (inhibition) of HDAC1 in T cells associated with acquired immune deficiency syndrome or hiv infection, repression and anticonvulsant
5) Confidence 0.25 Published 2006 Journal Genome Biol Section Body Doc Link PMC1431708 Disease Relevance 0.95 Pain Relevance 0.05
Upon exposure to AZA and TSA in combination, HDAC1 was remarkably depleted along with a reduced DNA methylation (Figure S2), whereas RNAPol-II and P-RNAPol-II were greatly enhanced, indicating transcription recovering (Figure 3, panel A).
Negative_regulation (depleted) of HDAC1
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997072 Disease Relevance 0 Pain Relevance 0.03
The absence of NES in HDAC1 and HDAC2 sequences attest to their nuclear localization [8].
Negative_regulation (absence) of HDAC1
7) Confidence 0.19 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.14 Pain Relevance 0

General Comments

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