INT177866

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.23
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

microtubule organizing center (BUB1B) cytoplasm (BUB1B) cytosol (BUB1B)
cell proliferation (BUB1B) mitosis (BUB1B) chromosome (BUB1B)
BUB1B (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 15 99.84 Very High Very High Very High
cINOD 12 94.76 High High
Inflammation 15 94.16 High High
adenocard 3 33.36 Quite Low
COX2 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 33 96.28 Very High Very High Very High
INFLAMMATION 15 94.16 High High
Colon Cancer 120 90.96 High High
Leukemia 9 89.92 High High
Cancer 27 82.64 Quite High
Metastasis 3 60.76 Quite High
Adhesions 12 24.68 Low Low
Retinoblastoma 3 13.76 Low Low
Hypersensitivity 15 5.00 Very Low Very Low Very Low
Stomach Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also other genes involved in transition through the G2/M phase of the cell cycle were downregulated by curcumin, like BUB1B and MAD2L1.
Negative_regulation (downregulated) of BUB1B
1) Confidence 0.32 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.43 Pain Relevance 0
Also after exposure to the low curcumin concentration some cell cycle genes were downregulated, like BUB1B (a mitotic checkpoint gene), STK6, STK12 and cyclin G1 (CCNG1).
Negative_regulation (downregulated) of BUB1B
2) Confidence 0.32 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.06 Pain Relevance 0
For example, expression of ASNS, ATF4 and MTHFD2 was upregulated by sulindac and expression of BUB1B and PDCD2 was downregulated by aspirin.
Negative_regulation (downregulated) of BUB1B associated with aspirin
3) Confidence 0.10 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.74 Pain Relevance 0.45

General Comments

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