INT177877

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.13
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AKR1C1) oxidoreductase activity (AKR1C1) cytoplasm (AKR1C1)
AKR1C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 2 62.08 Quite High
antagonist 1 45.32 Quite Low
aspirin 10 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 53 93.04 High High
Stomach Cancer 4 83.12 Quite High
Prostate Cancer 55 82.28 Quite High
Colon Cancer 80 59.04 Quite High
Cancer 54 57.08 Quite High
Apoptosis 22 55.32 Quite High
Adhesions 19 47.84 Quite Low
Disease 7 35.84 Quite Low
Hypersensitivity 11 5.00 Very Low Very Low Very Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in contrast to their findings, transcripts for AKR1C3, SRD5A1, HSD3B2, AKR1C2, AKR1C1 are not consistently upregulated in the metastatic samples in our study.
Neg (not) Positive_regulation (upregulated) of AKR1C1
1) Confidence 0.50 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.62 Pain Relevance 0
The most upregulated gene is aldo-keto reductase family 1 member C1 (AKR1C1).
Positive_regulation (upregulated) of AKR1C1
2) Confidence 0.44 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.25 Pain Relevance 0.03
The most upregulated gene is aldo-keto reductase family 1 member C1 (AKR1C1).
Positive_regulation (upregulated) of aldo-keto reductase family 1 member C1
3) Confidence 0.30 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

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