INT177880

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.74
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STAT5B) nucleoplasm (STAT5B) nucleus (STAT5B)
cytoplasm (STAT5B) signal transducer activity (STAT5B)
Anatomy Link Frequency
proximal region 1
T cells 1
STAT5B (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 77 96.88 Very High Very High Very High
Osteoarthritis 32 81.60 Quite High
Glutamate 3 72.28 Quite High
ischemia 2 55.92 Quite High
Arthritis 2 50.00 Quite Low
cytokine 16 37.84 Quite Low
Inflammation 18 5.00 Very Low Very Low Very Low
Leflunomide 15 5.00 Very Low Very Low Very Low
methotrexate 14 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunodeficiency 1 98.40 Very High Very High Very High
Frailty 34 98.20 Very High Very High Very High
Rheumatoid Arthritis 122 96.88 Very High Very High Very High
Adhesions 4 93.32 High High
Erythrocytosis 22 90.08 High High
Growth Problems 100 83.32 Quite High
Disease 33 77.96 Quite High
Myelodysplastic Syndromes 30 75.40 Quite High
Congenital Anomalies 1 69.32 Quite High
Syndrome 2 66.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is currently assumed that two boxes at the membrane-proximal region of the EPOR cytoplasmic domain and Y344 are the major positive motifs and that the activation of Stat5 is central for EPOR function [5].
Positive_regulation (activation) of Stat5 in proximal region
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.17 Pain Relevance 0.03
Other gene defects that have recently been discovered to result in growth failure include defects in the growth hormone receptor’s intracellular signaling, in particular, signal transducer and activator of transcription 5b (STAT5b),70 and a defect in the acid-labile subunit (ALS) of the circulating IGF-1 complex.71 STAT5b-deficiency results in a phenotype of GH-insensitivity and immunodeficiency, while ALS-deficient patients have rather subtle growth failure, with height tracking at about or just below the 3rd centile.
Positive_regulation (results) of STAT5b-deficiency associated with immunodeficiency
2) Confidence 0.29 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2898102 Disease Relevance 0.86 Pain Relevance 0
Moreover, patient erythroid precursors present an increased activation of EPOR and its effectors, including Stat5 and Erk1/2 pathway.


Positive_regulation (activation) of Stat5
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2916842 Disease Relevance 0.36 Pain Relevance 0.04
Upregulated signal transduction genes included STAT3 and STAT5b (Table 1) and some genes of the MAPK signal transduction pathway (MAP3K10, MAP4K2; table 1 and 2).
Positive_regulation (Upregulated) of STAT5b
4) Confidence 0.22 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.17 Pain Relevance 0
We identified elevated levels of phosphorylated (p)-AKT, p-p38, p-JNK, p-STAT1, p-STAT3, p-STAT5, p-ATF2, p-cdc2, p-p120, p-PKARIIb and p-src in joint infiltrating CD3+ T cells (Figure 1).
Positive_regulation (elevated) of p-STAT5 in T cells
5) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.18 Pain Relevance 0.40

General Comments

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