INT177886

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2006
Negated 3
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.42
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a)
protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)
Anatomy Link Frequency
urine 6
RG2 2
Cdkn2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 36 63.12 Quite High
agonist 3 62.16 Quite High
Dopamine 3 61.40 Quite High
antagonist 10 59.76 Quite High
adenocard 4 57.88 Quite High
imagery 27 46.64 Quite Low
ketamine 12 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Renal Failure 147 100.00 Very High Very High Very High
Glioblastoma 38 100.00 Very High Very High Very High
Apoptosis 146 92.68 High High
Cancer 88 55.40 Quite High
Natriuresis 3 55.40 Quite High
Colon Cancer 40 50.00 Quite Low
Brain Tumor 11 50.00 Quite Low
Malignant Neoplastic Disease 7 50.00 Quite Low
Necrosis 6 45.56 Quite Low
Renal Disease 27 42.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the same time point, expression of cyclin-dependent kinase inhibitor p16INK4 (CDKN2A) was upregulated (Table 2).
Positive_regulation (upregulated) of Gene_expression (expression) of p16INK4
1) Confidence 0.67 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.06 Pain Relevance 0
The present study has some limitations; 1) the number of animals used was small, 2) the rat ARF model may not well reflect human ARF, 3) creatinine levels were not constant after ARF and may depend on individual animal condition, 4) GFR was not calculated because urine creatinine levels were not measured, 5) the discrepancy between the creatinine levels and the degree of apoptosis observed in the two groups cannot be explained by proposed renal damage mechanism.
Neg (not) Positive_regulation (after) of Neg (not) Gene_expression (constant) of ARF in urine associated with acute renal failure and apoptosis
2) Confidence 0.40 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779283 Disease Relevance 0.94 Pain Relevance 0.20
The present study has some limitations; 1) the number of animals used was small, 2) the rat ARF model may not well reflect human ARF, 3) creatinine levels were not constant after ARF and may depend on individual animal condition, 4) GFR was not calculated because urine creatinine levels were not measured, 5) the discrepancy between the creatinine levels and the degree of apoptosis observed in the two groups cannot be explained by proposed renal damage mechanism.
Neg (not) Positive_regulation (after) of Neg (not) Gene_expression (reflect) of ARF in urine associated with acute renal failure and apoptosis
3) Confidence 0.40 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779283 Disease Relevance 0.96 Pain Relevance 0.21
The present study has some limitations; 1) the number of animals used was small, 2) the rat ARF model may not well reflect human ARF, 3) creatinine levels were not constant after ARF and may depend on individual animal condition, 4) GFR was not calculated because urine creatinine levels were not measured, 5) the discrepancy between the creatinine levels and the degree of apoptosis observed in the two groups cannot be explained by proposed renal damage mechanism.
Neg (not) Positive_regulation (after) of Gene_expression (model) of ARF in urine associated with acute renal failure and apoptosis
4) Confidence 0.40 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779283 Disease Relevance 0.96 Pain Relevance 0.21
Levels of p16, p21, Bax and AIF protein in BP-treated GBM cells were therefore measured, and protein expression levels of all four proteins increased in DBTRG-05MG and DBTRG 8401 cells; similar results for p27, Bax and AIF were detected in RG2 cells after treatment with BP (Figs 2b and c).
Positive_regulation (increased) of Gene_expression (Levels) of p16 in RG2 associated with glioblastoma
5) Confidence 0.07 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.51 Pain Relevance 0

General Comments

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