INT177936

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.10
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 2 99.54 Very High Very High Very High
rheumatoid arthritis 10 94.40 High High
Inflammation 29 92.32 High High
Kinase C 3 89.80 High High
cINOD 6 83.36 Quite High
Arthritis 6 67.20 Quite High
Rheumatism 1 66.40 Quite High
Inflammatory mediators 1 50.64 Quite High
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 99.38 Very High Very High Very High
Apoptosis 38 94.88 High High
Rheumatoid Arthritis 10 94.40 High High
Cancer 265 91.48 High High
Nerve Sheath Neoplasms 22 89.68 High High
Skin Cancer 51 87.52 High High
Arthritis 6 67.20 Quite High
Rheumatic Diseases 1 66.40 Quite High
Lung Cancer 5 52.56 Quite High
Adenocarcinoma 3 51.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, significant upregulation of VEGF-C mRNA (Figure 6C) and a decreased level of phosphorylated JNK (Figure 6D) were induced in EBC1-P4 cells treated with siRNA-podoplanin.
Positive_regulation (induced) of Negative_regulation (decreased) of JNK
1) Confidence 0.50 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.07 Pain Relevance 0
In addition, significant upregulation of VEGF-C mRNA (Figure 7B) and a decreased level of phosphorylated JNK (Figure 7C) were also induced in H157 cells treated with siRNA-podoplanin.
Positive_regulation (induced) of Negative_regulation (decreased) of JNK
2) Confidence 0.50 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.17 Pain Relevance 0
A decreased level of phosphorylated JNK but not of total JNK was induced by siRNA-mediated podoplanin knockdown (Figures 6D and 7C), suggesting that podoplanin could induce JNK phosphorylation.
Positive_regulation (induced) of Negative_regulation (decreased) of JNK
3) Confidence 0.34 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.27 Pain Relevance 0.04
In the present study, we further found that melittin and bee venom significantly reduced inflammatory stimuli (LPS and SNP)-induced activation of JNK signal, and the JNK signal specific inhibitor SP600215 suppressed the inhibitory effect of melittin and bee venom on the NF-?
Positive_regulation (activation) of Negative_regulation (inhibitor) of JNK associated with inflammatory stimuli
4) Confidence 0.13 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.86 Pain Relevance 0.43
Furthermore, Sulindac metabolites showed low activation of caspase-3, a common downstream regulator of SAPK/JNK [23,33].
Positive_regulation (activation) of Negative_regulation (regulator) of JNK
5) Confidence 0.06 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.74 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox