INT177940

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.77
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK9) nucleoplasm (MAPK9) mitochondrion (MAPK9)
nucleus (MAPK9) transcription factor binding (MAPK9) response to stress (MAPK9)
MAPK9 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 22 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
rheumatoid arthritis 96 97.30 Very High Very High Very High
Inflammation 31 85.84 High High
Osteoarthritis 126 85.16 High High
cINOD 17 81.36 Quite High
methotrexate 1 78.40 Quite High
fibrosis 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 11 100.00 Very High Very High Very High
Rheumatoid Arthritis 96 97.30 Very High Very High Very High
Shock 9 95.52 Very High Very High Very High
Apoptosis 67 92.44 High High
Cancer 99 87.08 High High
Colon Cancer 52 86.24 High High
INFLAMMATION 39 85.84 High High
Osteoarthritis 80 85.16 High High
Nerve Sheath Neoplasms 22 72.80 Quite High
Osteoporosis 12 66.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, an analysis of the differential gene expression shows that the present RA group is generally characterized by an expression profile highly compatible with previous gene expression studies [39], including the overexpression of several transcription factors (for example, FOS, FOSB, JUN, and STAT1 [10-12]), cytokines/chemokines (for example, IL2, IL4, CCL23, and CCL25 [40]), signal transduction molecules (for example, MAPK9, MAP3K2, PTPN7, and AKT2 [41,42]), cell cycle regulators (for example, CDC12, CCNB2, and CCNE2 [43]), and heat shock proteins (DNAJ molecules; [44]; data not shown), indicating that the present RA cohort is representative for RA patients in general.
Gene_expression (overexpression) of MAPK9 associated with chemokine, shock, rheumatoid arthritis and cytokine
1) Confidence 0.56 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.22 Pain Relevance 0.57
Inhibition of SAPK (SP600125) most robustly up-regulated ATF3 mRNA expression (Figure 2A).
Gene_expression (expression) of SAPK
2) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.65 Pain Relevance 0
SAPK/JNK and caspase-3 activation
Gene_expression (/) of SAPK
3) Confidence 0.15 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.43 Pain Relevance 0
also markedly increased the SAPK/JNK (p46 and p54), particularly the level of the p46 isoforms.
Gene_expression (/) of SAPK
4) Confidence 0.14 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.37 Pain Relevance 0.15
The levels of the phosphorylated mitogen-activated protein (MAP) kinases, extracellular signal-regulated kinase-1/2 (ERK1/2), p38, and stress-activated protein kinase/c-jun N-terminal kinase (SAPK/JNK) (p46 and p54) were determined on the cell lysate by Western blot as described below.


Gene_expression (/) of SAPK associated with stress
5) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.10 Pain Relevance 0

General Comments

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