INT177954

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Context Info
Confidence 0.07
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-E)
Anatomy Link Frequency
blood 2
HLA-E (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 54 100.00 Very High Very High Very High
cytokine 47 99.00 Very High Very High Very High
Inflammatory marker 1 71.08 Quite High
Inflammation 68 58.56 Quite High
antagonist 2 55.56 Quite High
corticosteroid 1 42.48 Quite Low
Inflammatory mediators 3 23.24 Low Low
Inflammatory response 15 16.92 Low Low
fibrosis 18 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Organ Transplantation 4 90.80 High High
Obesity 7 79.60 Quite High
Hypopigmentation 32 74.72 Quite High
INFLAMMATION 82 70.76 Quite High
Injury 31 50.00 Quite Low
Disease 12 46.68 Quite Low
Increased Venous Pressure Under Development 1 39.60 Quite Low
Cancer 4 34.28 Quite Low
Skin Cancer 2 34.00 Quite Low
Chronic Disease 2 29.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently, by repressing the induction of MHC-II, and subsequent T lymphocytes activation, the action of HMG-CoA reductase inhibitor, mostly used as lowering blood cholesterol agent, may provide new type of immuno modulation as suggested by our case report and literature on organ transplant recipients.


Negative_regulation (repressing) of Positive_regulation (induction) of MHC in blood associated with organ transplantation
1) Confidence 0.07 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC425594 Disease Relevance 0.28 Pain Relevance 0
By contrast, an n-3 polyunsaturated FA (docosahexaenoic acid), inhibits TLR4 agonist (LPS)-induced upregulation of the co-stimulatory molecules, MHC class II molecules, and cytokine production.
Negative_regulation (inhibits) of Positive_regulation (upregulation) of MHC associated with agonist and cytokine
2) Confidence 0.02 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.33 Pain Relevance 0.33

General Comments

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