INT177965

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Context Info
Confidence 0.25
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.11
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
lungs 2
mononuclear cells 2
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 28 98.88 Very High Very High Very High
rheumatoid arthritis 53 97.72 Very High Very High Very High
Inflammation 160 88.96 High High
cytokine 129 85.92 High High
antagonist 34 80.80 Quite High
aspirin 1 76.76 Quite High
agonist 20 76.72 Quite High
dexamethasone 2 56.48 Quite High
withdrawal 2 20.72 Low Low
Arthritis 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eosinophilia 46 99.96 Very High Very High Very High
Disease 66 98.48 Very High Very High Very High
Rheumatoid Arthritis 53 97.72 Very High Very High Very High
Asthma 318 90.20 High High
Rhinitis 49 89.60 High High
INFLAMMATION 164 88.96 High High
Recurrence 2 87.72 High High
Hypersensitivity 24 60.40 Quite High
Occupational Lung Diseases 16 59.68 Quite High
Gastritis 21 57.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In similar studies, montelukast decreases IL-4 mRNA expression in the lungs while increasing IFN-?
Negative_regulation (decreases) of Transcription (expression) of IL-4 in lungs
1) Confidence 0.25 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.80 Pain Relevance 0.41
Likewise, drastically reduced synthesis of IL-4 and IL-10 mRNA by synovial fluid mononuclear cells from RA patients correlates with disease activity [46].
Negative_regulation (reduced) of Transcription (synthesis) of IL-4 in mononuclear cells associated with rheumatoid arthritis and disease
2) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.73 Pain Relevance 0.27
Glucocorticoids, the most effective agents for reducing eosinophilia, suppress the gene transcription of IL-3, IL-4, IL-5, GM-CSF, and various chemokines [1].
Negative_regulation (suppress) of Transcription (transcription) of IL-4 associated with chemokine and eosinophilia
3) Confidence 0.06 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 0.59 Pain Relevance 0.10

General Comments

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