INT177991

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PXN) cell adhesion (PXN) plasma membrane (PXN)
cytoskeleton (PXN) cytoskeleton organization (PXN) cytoplasm (PXN)
Anatomy Link Frequency
macrophages 1
PXN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 81.92 Quite High
Crohn's disease 40 71.76 Quite High
cytokine 3 47.04 Quite Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Tendonitis 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 2 99.56 Very High Very High Very High
Cicatrix 2 84.48 Quite High
Inflammatory Bowel Disease 5 81.92 Quite High
Disease 37 71.12 Quite High
Myelodysplastic Syndromes 2 51.64 Quite High
Acute Myeloid Leukemia 1 50.88 Quite High
INFLAMMATION 2 44.52 Quite Low
Targeted Disruption 1 33.40 Quite Low
Fibromyalgia 2 29.96 Quite Low
Disease Susceptibility 9 12.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The localization of CSF1R in actin-rich areas of the cell is not surprising in view of data from in vitro studies demonstrating that the CSF1R protein mediates morphological changes in macrophages through the regulation of paxillin and focal adhesions [29].
Regulation (regulation) of paxillin in macrophages associated with adhesions
1) Confidence 0.04 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.48 Pain Relevance 0.10
3 integrins and an up regulation of phospho-paxillin and phospho-FAK in cell lysates compared to solid surfaces.
Regulation (regulation) of phospho-paxillin
2) Confidence 0.03 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2837661 Disease Relevance 0.08 Pain Relevance 0

General Comments

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