INT177992

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 16.14
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SNRNP70) mRNA processing (SNRNP70) RNA binding (SNRNP70)
nucleus (SNRNP70)
Anatomy Link Frequency
longitudinal muscle 2
blood 1
muscle cells 1
outer layers 1
upper 1
SNRNP70 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 40 99.20 Very High Very High Very High
Analgesic 76 98.96 Very High Very High Very High
cINOD 6 97.12 Very High Very High Very High
Opioid 25 96.68 Very High Very High Very High
Dopamine 23 95.42 Very High Very High Very High
Morphine 8 95.40 Very High Very High Very High
Myofascial pain syndrome 1 94.64 High High
Chronic pancreatitis 34 85.64 High High
addiction 34 85.00 Quite High
alcohol 20 84.56 Quite High
Disease Link Frequency Relevance Heat
Seborrhea 144 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 81 99.96 Very High Very High Very High
Schizophrenia 40 99.42 Very High Very High Very High
Burns 174 99.36 Very High Very High Very High
Anxiety Disorder 9 99.28 Very High Very High Very High
Disease 128 99.20 Very High Very High Very High
Coronary Artery Disease 105 99.18 Very High Very High Very High
Bacterial Respiratory Disease 54 96.40 Very High Very High Very High
Injury 103 95.76 Very High Very High Very High
Temporomandibular Joint Disorders 1 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although several rare COQ2 SNPs have been identified, we chose to focus on two SNPs that were most polymorphic and thus more likely to serve as informative markers for the gene.
Positive_regulation (several) of SNP
1) Confidence 0.49 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1832194 Disease Relevance 0.24 Pain Relevance 0
Although several rare COQ2 SNPs have been identified, we chose to focus on two SNPs that were most polymorphic and thus more likely to serve as informative markers for the gene.
Positive_regulation (rare) of SNP
2) Confidence 0.49 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC1832194 Disease Relevance 0.24 Pain Relevance 0
We chose haplotype tagging SNPs in C1orf9, FAM5C and the intergenic region 100 kilobases upstream and downstream of rs1324713.
Positive_regulation (tagging) of SNP
3) Confidence 0.49 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.65 Pain Relevance 0
The three SNPs (rs1048661, rs3825942, and rs2165241) in the LOXL1 gene, according to the previous report, were amplified by PCR and were directly sequenced [25].
Positive_regulation (amplified) of SNP
4) Confidence 0.45 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779059 Disease Relevance 0.34 Pain Relevance 0
SBD-2, SBD-3, and SNP-1 were upregulated in both enterocytes and Paneth cells, while SNP-1 and LL-37 showed increases in both the inner circular and outer longitudinal muscle layers of the muscularis externa following burn injury.
Positive_regulation (upregulated) of SNP-1 in longitudinal muscle associated with burns, injury and seborrhea
5) Confidence 0.37 Published 2010 Journal Eplasty Section Abstract Doc Link PMC2803769 Disease Relevance 1.91 Pain Relevance 0.04
If the PROSITE domain was defined as a regular expression, the second column was sufficient to identify whether the domain also existed in the presence of the SNP.
Spec (whether) Positive_regulation (presence) of SNP
6) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944825 Disease Relevance 0 Pain Relevance 0
Analyses for the individual SNP8 (rs6269) and SNP10 (rs4818) also did not show any significant association in our patient sample while Diatchenko et al. reported significant associations (p < 0.01).
Positive_regulation (individual) of SNP8
7) Confidence 0.35 Published 2006 Journal Mol Pain Section Body Doc Link PMC1543620 Disease Relevance 1.25 Pain Relevance 1.24
The upper two panels (a) show the dramatic increase in content of SNP-1 in the 2 layers of the externa (red/orange).
Positive_regulation (increase) of SNP-1 in upper
8) Confidence 0.27 Published 2010 Journal Eplasty Section Body Doc Link PMC2803769 Disease Relevance 0.93 Pain Relevance 0
Levels of SBD-2, SBD-3, SNP-1, and LL-37 increased, while SNP-1 and LL-37 showed increases in the externa, but LL-37 decreased significantly in the outer layers and the myenteric plexus following burn injury.
Positive_regulation (increases) of SNP-1 in outer layers associated with burns, injury and seborrhea
9) Confidence 0.25 Published 2010 Journal Eplasty Section Body Doc Link PMC2803769 Disease Relevance 0.98 Pain Relevance 0
LL-37 was clearly seen to be present in this layer (7c) but was virtually absent following burn, although slight, inconsistent increases of SBD-2, SBD-3, and SNP-1 did occur (images not shown).
Positive_regulation (increases) of SNP-1 associated with burns and seborrhea
10) Confidence 0.25 Published 2010 Journal Eplasty Section Body Doc Link PMC2803769 Disease Relevance 1.23 Pain Relevance 0
SBD-2, SBD-3, and SNP-1 were upregulated in both enterocytes and Paneth cells, while SNP-1 and LL-37 showed increases in both the inner circular and outer longitudinal muscle layers of the muscularis externa following burn injury.
Positive_regulation (increases) of SNP-1 in longitudinal muscle associated with burns, injury and seborrhea
11) Confidence 0.25 Published 2010 Journal Eplasty Section Abstract Doc Link PMC2803769 Disease Relevance 1.92 Pain Relevance 0.04
It was unclear whether the observed elevated mutation rate at brick SNP sites reflects effects specific to these particular sites or a local selective pressure relaxation in a larger region encompassing the SNP position.
Positive_regulation (elevated) of SNP
12) Confidence 0.24 Published 2010 Journal Molecular Biology and Evolution Section Body Doc Link PMC2872621 Disease Relevance 0 Pain Relevance 0
We also discovered a pronounced deviation from the evolutionary predisposition in the human lineage, with over 20-fold increase in the substitution rate at brick SNP sites over expected values.
Positive_regulation (increase) of SNP
13) Confidence 0.24 Published 2010 Journal Molecular Biology and Evolution Section Abstract Doc Link PMC2872621 Disease Relevance 0 Pain Relevance 0
It is unclear whether a possible loss of purifying selection in hominoids could be the primary explanation for the observed high variability rate in brick SNP nucleotides.
Positive_regulation (explanation) of SNP
14) Confidence 0.24 Published 2010 Journal Molecular Biology and Evolution Section Body Doc Link PMC2872621 Disease Relevance 0 Pain Relevance 0
When burn samples were compared to sham tissues, SBD-2, SBD-3, and SNP-1 content was increased, SBD-1 content was decreased, and there was little or no change in LL-37 content (Fig 3, antimicrobials shown in red).
Positive_regulation (increased) of SNP-1 associated with burns, bacterial respiratory disease and seborrhea
15) Confidence 0.22 Published 2010 Journal Eplasty Section Body Doc Link PMC2803769 Disease Relevance 0.72 Pain Relevance 0
Endothelial dysfunction refers usually to a blunted vasodilatory response to Ach, which releases NO from the endothelium, while the vasorelaxant activity of SNP or nitroglycerin, which act as NO donors in vascular muscle cells, is maintained (Deanfield et al 2005).
Positive_regulation (activity) of SNP in muscle cells
16) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.71 Pain Relevance 0
Polarity was adapted to the electric charge of the vasoactive molecule (chamber positive for Ach and negative for SNP).
Positive_regulation (negative) of SNP
17) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 0.17 Pain Relevance 0
We found no statistically significant differences in distribution of CAT alleles in studied SNP and no impact of this SNP on the presence of vascular complications and the level of glycated haemoglobin.
Positive_regulation (distribution) of SNP
18) Confidence 0.07 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.29 Pain Relevance 0
Still, since a SNP is a genetic variation occurring in ?
Positive_regulation (occurring) of SNP
19) Confidence 0.07 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684124 Disease Relevance 0 Pain Relevance 0
Thirty-four subjects (28 patients, 6 controls) with unambiguous TaqMan® SNP genotyping were sequenced for SNP 1 and 2 using Big Dye chemistry (Applied Biosystems, Foster City, California, USA) at a 1:4 dilution, but otherwise according to the manufacturer's directions.
Positive_regulation (sequenced) of SNP 1
20) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2626574 Disease Relevance 0.72 Pain Relevance 0.76

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