INT177996

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Context Info
Confidence 0.01
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.01
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FOXI2) transcription factor binding (FOXI2)
Anatomy Link Frequency
bowel 1
FOXI2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 97.36 Very High Very High Very High
Crohn's disease 40 86.84 High High
cytokine 3 75.36 Quite High
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 100.00 Very High Very High Very High
Inflammatory Bowel Disease 5 97.36 Very High Very High Very High
Fibromyalgia 2 96.96 Very High Very High Very High
Disease 37 86.84 High High
INFLAMMATION 2 80.72 Quite High
Disease Susceptibility 9 79.20 Quite High
Acute Myeloid Leukemia 1 69.12 Quite High
Myelodysplastic Syndromes 1 66.64 Quite High
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is significant because targeted disruption of either the G alpha i2 gene or the Stat3 transcription factor (in monocytes) results in inflammatory bowel disease in rodents [22,23].
Negative_regulation (disruption) of i2 in bowel associated with targeted disruption and inflammation
1) Confidence 0.01 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 1.01 Pain Relevance 0.34

General Comments

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