INT177998

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 7.12
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (RUNX1) nucleus (RUNX1) DNA binding (RUNX1)
transcription factor binding (RUNX1)
RUNX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Etanercept 6 99.88 Very High Very High Very High
Crohn's disease 120 99.40 Very High Very High Very High
Adalimumab 5 97.88 Very High Very High Very High
Infliximab 8 95.36 Very High Very High Very High
cytokine 11 93.92 High High
Inflammation 31 93.56 High High
rheumatoid arthritis 73 91.08 High High
psoriasis 6 87.84 High High
Arthritis 21 85.52 High High
spinal inflammation 11 84.40 Quite High
Disease Link Frequency Relevance Heat
Precursor Cell Lymphoblastic Leukemia-lymphoma 112 100.00 Very High Very High Very High
Acute Myeloid Leukemia 57 100.00 Very High Very High Very High
Louse Infestation 2 99.66 Very High Very High Very High
Disease Susceptibility 27 99.08 Very High Very High Very High
Disease 175 98.72 Very High Very High Very High
Nicotine Addiction 14 97.04 Very High Very High Very High
Cancer 36 96.56 Very High Very High Very High
Necrosis 2 94.60 High High
INFLAMMATION 16 93.56 High High
Leukemia 188 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The three most important SNPs for the prediction were PTPN22*rs2476601, MAP3K71P2*rs577001, and RUNX1*rs2268277.
RUNX1 Binding (rs2476601) of
1) Confidence 0.35 Published 2007 Journal BMC Proc Section Body Doc Link PMC2367463 Disease Relevance 0.30 Pain Relevance 0.11
Interestingly, a missense substitution in SLC22A4, a gene in this region that is a downstream target of the transcription factor, Runx1, is associated with susceptibility to Crohn's disease [11].
Runx1 Binding (associated) of associated with crohn's disease and disease
2) Confidence 0.18 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 1.07 Pain Relevance 0.51
Since the CSF1R gene is a target of RUNX1 and has multiple RUNX1 binding sites in several introns [35], complete sequencing of each of these sites will be performed to investigate the hypothesis that defective RUNX1 binding is related to Crohn's disease susceptibility [36].


RUNX1 Binding (binding) of associated with disease susceptibility and crohn's disease
3) Confidence 0.17 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.88 Pain Relevance 0.22
We do not know what the significance, if any, is of the location of the A2033T SNP near a binding site for the transcription factor, RUNX1.
RUNX1 Binding (binding) of
4) Confidence 0.17 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.88 Pain Relevance 0.21
Etanercept is a fusion protein that binds TNF and has also been shown to neutralize lymphotoxin alpha which is associated with tumour growth control [5].
fusion protein Binding (binds) of associated with cancer and etanercept
5) Confidence 0.01 Published 2009 Journal The Open Rheumatology Journal Section Body Doc Link PMC2714577 Disease Relevance 1.89 Pain Relevance 0.76
In a recent case–control study conducted in France, for the first time insecticidal shampoo treatment of pediculosis was found to be associated with childhood ALL and AML (OR = 1.9; 95% CI, 1.2–3.3) (Menegaux et al. 2006).
AML Binding (associated) of associated with precursor cell lymphoblastic leukemia-lymphoma, acute myeloid leukemia and louse infestation
6) Confidence 0.01 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1817663 Disease Relevance 0.72 Pain Relevance 0.10
Maternal marijuana use before and during pregnancy has been associated with childhood AML and ALL.
AML Binding (associated) of associated with precursor cell lymphoblastic leukemia-lymphoma and acute myeloid leukemia
7) Confidence 0.01 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1817663 Disease Relevance 1.37 Pain Relevance 0.16

General Comments

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