INT178002

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 6.52
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CSF1R) signal transduction (CSF1R) plasma membrane (CSF1R)
Anatomy Link Frequency
bowel 1
CSF1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 388 100.00 Very High Very High Very High
Crohn's disease 44 99.62 Very High Very High Very High
Inflammation 69 99.20 Very High Very High Very High
spastic colon 4 98.00 Very High Very High Very High
chemokine 48 94.48 High High
cytokine 51 86.36 High High
Pain 36 83.12 Quite High
rheumatoid arthritis 22 74.56 Quite High
headache 4 65.80 Quite High
Catechol-O-methyltransferase 16 50.08 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 390 100.00 Very High Very High Very High
Disease 85 99.62 Very High Very High Very High
Infection 8 99.50 Very High Very High Very High
INFLAMMATION 70 99.20 Very High Very High Very High
Syndrome 28 98.80 Very High Very High Very High
Familial Mediterranean Fever 100 98.54 Very High Very High Very High
Functional Bowel Disorder 4 98.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 96.96 Very High Very High Very High
Disease Susceptibility 13 93.20 High High
Pain 40 83.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that rare mutations on a single haplotype in the MEFV gene cause milder symptoms than those in the compound heterozygous state associated with FMF or, more likely, that additional factors present in the environment may trigger FMS.
Spec (may) Positive_regulation (trigger) of FMS associated with familial mediterranean fever and fibrositis
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.61 Pain Relevance 0.17
Indeed, a high prevalence of FMS was observed among offspring of FMS mothers.
Positive_regulation (prevalence) of FMS associated with fibrositis
2) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 2.20 Pain Relevance 0.98
Given the large number of NLR genes and their growing number of disease associations, it is likely that more NLR gene variants will be found as risk factors for FMS, and that specific chronic infections will be identified that trigger FMS via their interactions with these genes.
Positive_regulation (trigger) of FMS associated with disease, fibrositis and infection
3) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 1.14 Pain Relevance 0.40
Possible immunological triggers for FMS include intestinal inflammation such as found in irritable bowel syndrome (IBS), a condition found in a large percentage (ca. 50%) of FMS patients [23], [24].
Positive_regulation (triggers) of FMS in bowel associated with inflammation, spastic colon and fibrositis
4) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 1.63 Pain Relevance 0.72
Using microarray analysis to examine gene expression in endoscopic colonic biopsies from patients with newly diagnosed, untreated Crohn's disease, we identified an overexpressed gene on 5q33, CSF1R (unpublished data).
Positive_regulation (overexpressed) of CSF1R associated with crohn's disease and disease
5) Confidence 0.19 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 0.85 Pain Relevance 0.46

General Comments

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