INT178004

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.45
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SLC22A4) transmembrane transporter activity (SLC22A4) plasma membrane (SLC22A4)
transmembrane transport (SLC22A4)
SLC22A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 77 99.04 Very High Very High Very High
cytokine 4 96.60 Very High Very High Very High
rheumatoid arthritis 2 90.00 High High
Inflammation 18 89.84 High High
Bile 2 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 94 98.72 Very High Very High Very High
Disease Susceptibility 12 95.32 Very High Very High Very High
Inflammatory Bowel Disease 26 90.40 High High
Rheumatoid Arthritis 2 90.00 High High
Autoimmune Disease 3 88.00 High High
Primary Sclerosing Cholangitis 21 81.04 Quite High
INFLAMMATION 13 78.60 Quite High
Biliary Liver Cirrhosis 15 78.24 Quite High
Colitis 3 70.72 Quite High
Genetic Predisposition To Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We confirmed a strong association between three NOD2/CARD15 gene variants (Pro268Ser, OR = 2.52, 95% CI = 1.34 – 4.75); (Arg702Trp, OR = 6.65, 95% CI = 1.99 – 22.17); (1007fs, OR = 9.59, 95% CI = 3.94 – 23.29), and a weak association between both the protective OCTN1/OCTN2 CC haplotype (OR = 0.28, 95% CI = 0.08 – 0.94), and a variant of ATG16L1 gene (Thr300Ala, OR = 0.468, 95% CI = 0.24 – 0.90) with Crohn's disease.
OCTN1 Binding (association) of associated with crohn's disease and disease
1) Confidence 0.26 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2535589 Disease Relevance 1.35 Pain Relevance 0.25
Interestingly, a missense substitution in SLC22A4, a gene in this region that is a downstream target of the transcription factor, Runx1, is associated with susceptibility to Crohn's disease [11].
SLC22A4 Binding (associated) of associated with crohn's disease and disease
2) Confidence 0.14 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 1.10 Pain Relevance 0.52

General Comments

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